Sentences with phrase «nearby genes»

Moreover, disease - causing variants in DNA often do not act directly, but by activating nearby genes.
When Shi's group used the technique of RNA interference (RNAi) to reduce levels of the enzyme in human cells, specific histones were methylated and expression of nearby genes increased, the team reported in the 16 December online version of Cell.
They identified three nearby genes responsible for transport in and out of the cell, and upon transferring these specific genes to E. coli, were able to produce an elusive TDA resistant bacterial strain.
Further, investigation of these CpG associations revealed nearby genes whose RNA expression was altered in brain samples with Alzheimer's disease: ANK1, CDH23, DIP2A, RHBDF2, RPL13, RNF34, SERPINF1 and SERPINF2.
In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itself.
And rather than looking at genes, as most research in the past has done, they examined DNA regions that don't code for genes but instead regulate how nearby genes are expressed.
The co-factors work like miniature pep squads, spurring nearby genes into activity.
With the statistical power of 2,000 samples (half in a discovery set, half in a validation set), they were able to search for both cis - regulatory (variants affecting nearby genes) and trans - regulatory (variants affecting distant genes) relationships.
In the illustration, each tissue type is followed by the number of genes whose level of activity is controlled by nearby genes on the same chromosome (cis); those whose activity is associated with genes on other chromosomes (trans); and the number of tissue samples studied.
The problem is that they insert genes at random locations in the genome, as well as inserting regulatory sequences that can sometimes activate nearby genes and trigger cancer.
Dramatic changes in DNA methylation, a process that usually quashes activity of nearby genes, occur during the first six months of brain development, researchers report February 3 in Genome Research.
While a conventional gene's RNA serves as a blueprint for protein, SRG1 fervently spits out many useless copies of RNA, which effectively stop a nearby gene in its tracks.
Most of the variants found by OncoArray were not found within genes, but rather within regions of the genome that regulate the activity of nearby genes.
These are the same T cell genes inhibited by digoxin, and since replication of integrated HIV - 1 requires transcription of nearby genes, this provides an explanation for why wild type HIV - 1 is more susceptible to digoxin: digoxin represses the genes that the virus more frequently targets for integration.
«We found that 5 to 10 percent of these chromosome modifications were different in children born through assisted reproduction, and this altered the expression of nearby genes,» Sapienza says.
Erlich used a multitude of statistical genetic and integrative genomics analyses to reveal that STRs have a function: they act like springs or knobs that can expand and contract, and fine - tune the nearby gene expression.
Such SNPs can then guide scientists to the nearby genes that cause the disease, the same way a corner gas station might serve as a landmark to guide visitors to your neighborhood and eventually to your house.
Thus, despite the disappearance of nearby genes, these genes have persisted on the Y chromosome, the team reports online today in Nature.
MLL2 can add the H3K4me3 mark without any nearby gene activity while another process, that doesn't use MLL2, places the same mark around active genes.
Previous work had shown that the DNA region in question, a promoter located on chromosome 17, switches on a nearby gene coding for a protein that shuttles serotonin back into nerve cells so they can reuse it as a neurotransmitter.
It wasn't on the OCA gene but rather on a nearby gene called HERC2.
lentiviral vectors contain a deletion in the 3» LTR that prevents aberrant activation of nearby genes.
Self - inactivating (SIN) lentiviral vectors contain a deletion in the 3» LTR that prevents aberrant activation of nearby genes.
With the encouragement of an early mentor, he volunteered at a nearby gene therapy lab through an after - school program for gifted students.
The frequency of that allele increases so rapidly that there's no time for recombination — the shuffling of nearby genes — to take place.
When annotated with snpEff, there are more than 80 million variants within or nearby genes, where they might play a regulatory role (again, multiple transcripts = multiple annotations per variant).
One obvious category of such variants is «regulatory SNPs» whose alleles modulate the expression of nearby genes.

Phrases with «nearby genes»

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