Once caused primarily by heavy tobacco or alcohol use, the majority of new head and
neck cancers in the United Stated result from infection with HPV, a common sexually transmitted disease known for causing cervical cancer in women.
Between 61 % and 86 % of people diagnosed with head and
neck cancers in England survive their disease for one year or more (2009 - 13).
Between 28 % and 67 % of people diagnosed with head and
neck cancers in England survive their disease for five years or more (2009 - 13).
Having only people with head and
neck cancers in the study eliminates the variability of a group suffering from different forms of the disease, but it also eliminates information about whether patients with other forms of cancer would show the same results.
The man, identified in a medical journal case report only as «Mr. S,» had been on chemotherapy to keep his head and
neck cancer in check.
Not exact matches
The procedure was done
in the
neck of a 12 - year - old boy who had developed
cancer.
Iodine is absorbed and used by the thyroid gland
in the
neck, so radioactive forms can concentrate there and promote
cancer.
Neuhaus had
cancer in his lymph nodes, especially
in his
neck and around his lungs, but it was not clear exactly what kind it was.
Last time I checked, Meredith Viera isn't a doctor and Nancy Snyderman specializes
in head and
neck cancer, not obstetrics (not that she writes the story, but you know what I mean).
He founded the organization
in 2001 after his 21 - year - old daughter Abigail died from head and
neck cancer.
She and other colleagues first noticed an odd shift
in patient profiles
in the late 1990s: younger men were showing up
in her clinic, often with no significant history of smoking or heavy drinking, which are risk factors for head and
neck cancers.
Previous studies by the University of South Carolina's Lucia Pirisi - Kim Creek research group had reported the existence of an HPV - inactive class
in head and
neck cancers and raised the possibility that HPV - inactive cervical
cancers might originate as virally driven
cancers and subsequently act independent of HPV.
Even though this is a relatively rare
cancer, we know HPV is important
in a number of other tumors, including those of the head and
neck.
The study, was reported Feb 13 to the 5th International Conference on Innovative Approaches
in Head and
Neck Oncology (ICHNO) will reduce significantly the number of HNSCC patients who currently undergo selective
neck dissection (SND), a procedure which involves removing a group of lymph nodes from the
neck in order to try to eradicate those which may have been reached by the
cancer.
«New radiotracer helps avoid
neck dissection
in patients with early head and
neck cancer.»
A new tracer can enable surgeons to make an accurate identification of the sentinel node — the lymph node to which
cancer spreads first — and hence spare patients the post-operative complications that may be linked to the removal of a group of lymph nodes
in the
neck.
Immunotherapy doubles overall survival and improves quality of life, with fewer side effects,
in a treatment - resistant and rapidly progressing form of head and
neck carcinoma, reports a large, randomized international trial co-led by investigators at the University of Pittsburgh
Cancer Institute (UPCI).
Cancer in the thyroid, which is located just below the «Adam's apple» area of the neck, is the fifth most common cancer diagnosed in
Cancer in the thyroid, which is located just below the «Adam's apple» area of the
neck, is the fifth most common
cancer diagnosed in
cancer diagnosed
in women.
A similar virus, called H101, is already marketed
in China to treat head and
neck cancers.
Finally, a Calgary, Alberta — based company, Oncolytics Biotech, is testing a reovirus (an RNA virus often found
in human lungs but thought to be nonpathogenic) against several types of
cancer, including that of the lung and skin as well as head and
neck malignancies.
Heeke says the study would be open to people whose tumors have evidence of HRD like those found
in this study, which includes bladder, breast, cervix, liver and bile duct, colorectal, endometrial, gastric / esophageal, head &
neck, kidney, neuroendocrine, lung, ovarian, pancreas, prostate, sarcoma, and thyroid
cancers, as well as gastrointestinal stromal tumors, glioma, melanoma and unknown primary
cancers.
In 2011 the National Toxicology Program at the Department of Health and Human Services declared formaldehyde a known human carcinogen, demonstrated by human and animal studies to cause
cancer of the nose, head,
neck and lymphatic system.
Dr. Islam saw this phenomenon occur
in cell culture and
in some samples from patients with head and
neck cancers.
Researchers at Oregon State University are pursuing a new concept
in treatment of epithelial
cancer, especially head and
neck cancer, by using two promising «analogs» of an old compound that was once studied as a potent anti-tumor agent, but long ago abandoned because it was too toxic.
Yang et al. report on one such strategy: Taking the knowledge that an increase
in type I interferons (IFNs) correlates positively with clinical outcome
in several
cancers and that type I IFNs can enhance antitumor immunity
in some models, the authors tethered IFN - β to a monoclonal antibody targeting the epithelial growth factor receptor (EGFR), which is approved for use
in treating metastatic colorectal
cancer and head and
neck cancer.
The effects of the pactamycin analogs, called TM - 025 and TM - 026, were characterized
in head and
neck cancer cell lines, which cause the eighth most common
cancer in the world.
The vaccine may also prevent head and
neck cancer, which has been on the rise
in recent years.
And although the vaccine has not been proven to prevent head and
neck cancers, which can also be caused by HPV, the recent rise
in cases of these
cancers likely factored into the panel's reasoning for the recommendation, Schaffner said.
In stage T4a larynx
cancer the tumor grows through the thyroid cartilage and / or into tissues beyond the larynx, such as the thyroid gland, trachea, esophagus, tongue muscles, or
neck muscles.
Men who had smoked were nearly twice as likely to die from
cancer, especially lung
cancer, but there was also an elevated risk of death from
cancers of the head and
neck, esophagus, stomach, colorectum, liver, pancreas and bladder — all diseases that have been linked to smoking
in previous studies, according to the authors.
Specifically, data from the
Cancer Genome Atlas showed signatures of APOBEC3 - mediated mutations
in the PIK3CA gene of about 40 percent of HPV - positive head and
neck cancers, but only about 10 percent of HPV - negative head and
neck cancers.
To investigate why checkpoint inhibitors so often stop working, Velculescu; Valsamo Anagnostou, M.D., Ph.D., instructor of oncology at the Johns Hopkins University School of Medicine; Kellie N. Smith, Ph.D., a
cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-
cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for
Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-
Cancer Immunotherapy studied tumors of four patients with non-small cell lung
cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-
cancer and one patient with head and
neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-
cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or
in combination with a second drug called ipilimumab, which uses an antibody called anti-CTLA4.
The results of the mouse, human and lab studies have been so successful that Dr. Bauman has started a larger clinical trial
in volunteers previously cured of head and
neck cancer.
Prior research has found that almost all head and
neck cancer cells display an over-abundance of the protein, and it had been suggested
in the literature as a potential target.
Dr. Bauman also collaborated with senior author Daniel E. Johnson, Ph.D., professor of medicine at Pitt and a senior scientist
in the UPCI Head and
Neck Cancer Program, to see how the extract performed in mice predisposed to head and neck c
Cancer Program, to see how the extract performed
in mice predisposed to head and
neck cancercancer.
«People who are cured of head and
neck cancer are still at very high risk for a second cancer in their mouth or throat, and, unfortunately, these second cancers are commonly fatal,» said lead author Julie Bauman, M.D., M.P.H., co-director of the UPMC Head and Neck Cancer Center of Excel
cancer are still at very high risk for a second
cancer in their mouth or throat, and, unfortunately, these second cancers are commonly fatal,» said lead author Julie Bauman, M.D., M.P.H., co-director of the UPMC Head and Neck Cancer Center of Excel
cancer in their mouth or throat, and, unfortunately, these second
cancers are commonly fatal,» said lead author Julie Bauman, M.D., M.P.H., co-director of the UPMC Head and
Neck Cancer Center of Excel
Cancer Center of Excellence.
«Green chemoprevention requires less money and fewer resources than a traditional pharmaceutical study, and could be more easily disseminated
in developing countries where head and
neck cancer is a significant problem.»
«Compound
in magnolia may combat head and
neck cancers: Honokiol, from magnolia bark, shuts down
cancer cells
in lab.»
Dr. Bauman and her colleagues treated human head and
neck cancer cells
in the laboratory with varying doses of sulforaphane and a control, and compared them to normal, healthy cells that line the throat and mouth.
This research is funded through Pitt's Specialized Program of Research Excellence grant
in head and
neck cancer from the National Cancer Inst
cancer from the National
Cancer Inst
Cancer Institute.
«Antacids linked to better survival
in head and
neck cancer.»
According to the National
Cancer Institute, at least 3
in 4 head and
neck cancers are caused by the use of tobacco and alcohol.
This study, «Final Results of Local - Regional Control and Late Toxicity of RTOG 9003: A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head and
Neck Cancer,» is a multi-institutional, randomized Phase III trial of fractionation in locally advanced head and neck c
Cancer,» is a multi-institutional, randomized Phase III trial of fractionation
in locally advanced head and
neck cancercancer.
«The decrease
in the rate of new
cancers was unexpected; however, the large database and the long follow - up provided us with a window into information that had not previously been available about the long - term patterns of head and
neck tumors and is particularly heartening.
«This study, one of only a few large studies to have follow - up beyond five years, demonstrates that patients who have head and
neck cancers and who are being treated with radiation therapy alone have improved local - regional control and no increase
in late toxicity when radiation therapy is delivered twice a day
in two smaller doses which we call hyperfractionation,» said Jonathan J. Beitler, MD, MBA, FASTRO, lead author of the study and professor of radiation oncology, otolaryngology and hematology / medical oncology at the Winship
Cancer Institute of Emory University School of Medicine
in Atlanta.
Human papilloma virus (HPV), the culprit behind cervical
cancer and some forms of head and
neck cancer may hide
in small pockets on the surface of tonsils
in people not known to carry the virus.
A similar rearrangement of collagen has also been found
in breast
cancer, head,
neck, esophageal and colorectal
cancers.
While verified tests exist to detect HPV
in people before they develop cervical
cancer, the same is not true for HPV - related head and
neck cancers, which are expected to outnumber cervical
cancer cases by 2020.
It's also known to play a role
in a form of leukemia, as well as liver
cancer, squamous cell skin carcinomas, squamous cell
cancers of the head and
neck and other
cancers.
A class of therapeutic drugs known as protein kinase inhibitors has
in the past decade become a powerful weapon
in the fight against various life - threatening diseases, including certain types of leukemia, lung
cancer, kidney
cancer and squamous cell
cancer of the head and
neck.