Sentences with word «necroptosis»

The Max Planck researchers then showed that less necroptosis of endothelial cells and less metastasis occur in genetically modified animals in which Death Receptor 6 is disabled.

248/3: 30 Necroptosis in Niemann - Pick Disease, type C1: A potential therapeutic target.

The research team also found that the action of a gene, ATG16L1, kept TNF alpha - driven inflammation from triggering the self - destruction of too many Paneth cells, by an explosive process called necroptosis.

Moreover they discovered that in contrast, necroptosis prevents uninhibited cell proliferation and consequently the development of liver cancer.

This process, known as necroptosis, enabled cancer cells to overcome an endothelial cell layer in the laboratory.

These data reveal that the tissue damage present in this SIRS model is reflected, in part, by breaks in the vasculature due to endothelial cell necroptosis and thereby predict that RIPK1 kinase inhibitors may provide clinical benefit to shock and / or sepsis patients.

There, in a quest to develop targeted therapies for ovarian cancer, she began studying necroptosis, a form of programmed cell death.

Chefetz is continuing her search for necroptosis - based targeted therapies for ovarian cancer at the University of Minnesota, where she accepted an assistant professorship last year.

«We would like to accelerate necroptosis to kill as many cancer stem cells [as possible],» she says.

«We used to think... necroptosis happens due to injury, ischemia, inflammation, and so on,» Chefetz says.

How neutrophils die or survive along NET release and is «NETosis» = necroptosis?

The group demonstrated that the AMPs directly act on the virus, rather than just inducing apoptosis or necroptosis of the infected cells as others were seen to do.

Receptor interacting protein kinase 1 (RIPK1) has important kinase - dependent and kinase - independent scaffolding functions that activate or prevent apoptosis or necroptosis in a cell...

Currently, she is investigating how inhibiting aldehyde dehydrogenase can kill ovarian cancer stem cells by inducing necroptosis.

A distinction is made between the two most important forms of self - induced cell death, namely apoptosis (programmed cell death) and necroptosis (programmed necrosis), which are based on different cellular mechanisms.

This marks the start of the cancer cells» attack on the vascular wall, which culminates in the necroptosis of wall cells,» Strilic explains.

Receptor interacting protein kinase 1 (RIPK1) has important kinase - dependent and kinase - independent scaffolding functions that activate or prevent apoptosis or necroptosis in a cell context — dependent manner.

Research Interests: alcoholic liver disease; macrophages; C1q; apoptosis; fibrosis; liver disease; alcohol; Heme - oxygenase - 1; inflammation; necroptosis; high - fat diet; liver injury; fatty liver disease; complement; hepatocytes; alcoholic hepatitis; hepatic stellate cell; adiponectin; MIF; carbon tetrachloride

Differential roles of RIPK1 and RIPK3 in TNF - induced necroptosis and chemotherapeutic agent - induced cell death