The group demonstrated that the AMPs directly act on the virus, rather than just inducing apoptosis or
necroptosis of the infected cells as others were seen to do.
The Max Planck researchers then showed that less
necroptosis of endothelial cells and less metastasis occur in genetically modified animals in which Death Receptor 6 is disabled.
Not exact matches
The research team also found that the action
of a gene, ATG16L1, kept TNF alpha - driven inflammation from triggering the self - destruction
of too many Paneth cells, by an explosive process called
necroptosis.
There, in a quest to develop targeted therapies for ovarian cancer, she began studying
necroptosis, a form
of programmed cell death.
Characterization
of RIPK3 - mediated phosphorylation
of the activation loop
of MLKL during
necroptosis.
Differential roles
of RIPK1 and RIPK3 in TNF - induced
necroptosis and chemotherapeutic agent - induced cell death
Recently, RIPK3 was demonstrated to require a Bax / Bak effect on the mitochondrial permeability transition pore to carry out
necroptosis, and the importance
of both RIPK1 and RIPK3 in relation to
necroptosis - directed degenerative, inflammatory, and infectious diseases has been published (Moriwaki et al., 2015).