Sentences with phrase «necrosis factor in»

More discussion on this important study can be found at: Tumor necrosis factor in colitis — bad actor or hero?

Ferdy Lejeune and colleagues report the first study of isolated limb perfusion with tumor necrosis factor in patients with melanoma and sarcoma.

Bruce Beutler and Anthony Cerami provide the first demonstration of the role of tumor necrosis factor in the pathogenesis of disease.

Not exact matches

Researchers at NYU School of Medicine found that the value of the drug infliximab, marketed as Remicade, in both applications proceeds from its ability to block the contribution of the protein tumor - necrosis factor alpha, or TNF alpha, to problem - causing inflammation.

The second gene, TNFRSF6B, encodes a receptor related to those that bind tumor necrosis factor (TNF)-- a key chemical signal for triggering inflammation in IBD as well as in patients with other autoimmune disorders such as rheumatoid arthritis and psoriasis.

In contrast, men have greater tumor necrosis factor - alpha, homocysteine and uric acid levels as well as higher coronary artery calcium score than women.

For 5 years, Beckmann was engrossed in many research projects, including an investigation of tumor necrosis factor receptors (TNFRs).

According to Dr. Schwarz, «We observed acute proinflammatory changes, namely, leukocytosis, neutrophilia, upregulated levels of IL - 6 in serum, and enhanced messenger RNA expression of IL - 6 and tumor necrosis factor alpha.

But two cytokines — interleukin - 17 (IL - 17) and tumor necrosis factor (TNF)-- are overexpressed in psoriasis, leading the immune system to attack a person's own skin cells.

The rate of heart attacks was lower in the biologic group, generating an adjusted hazard ratio of heart attacks of 0.61 in the tumor necrosis factor group compared to the DMARD group.

«Using tumor necrosis factor inhibitors decreases risk of heart attacks in rheumatoid arthritis patients.»

The researchers determined that the children with otulipenia might respond to drugs that turned off tumor necrosis factor, a chemical messenger involved in systemic inflammation.

In a previous study published in 2012, researchers treated psoriasis patients with antibodies that attack IL - 17A and with a substance, called an antagonist, that acts against tumour necrosis factor, another cytokine strongly implicated in psoriasiIn a previous study published in 2012, researchers treated psoriasis patients with antibodies that attack IL - 17A and with a substance, called an antagonist, that acts against tumour necrosis factor, another cytokine strongly implicated in psoriasiin 2012, researchers treated psoriasis patients with antibodies that attack IL - 17A and with a substance, called an antagonist, that acts against tumour necrosis factor, another cytokine strongly implicated in psoriasiin psoriasis.

In 2012, Dr. Krolewski and his team made a very important discovery when they found a link between tumor necrosis factor receptor 1 (TNFR1) and declining renal function in type 1 and type 2 diabeteIn 2012, Dr. Krolewski and his team made a very important discovery when they found a link between tumor necrosis factor receptor 1 (TNFR1) and declining renal function in type 1 and type 2 diabetein type 1 and type 2 diabetes.

Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.

Infliximab reduces symptoms and inflammation by targeting one of the proteins — called tumor necrosis factor (TNF)-- that leads to inflammation in IBD.

Such is the case for a DNA letter in the gene that encodes the protein called tumour necrosis factor receptor 1 (TNFR1).

The protein senses a potent immune molecule called tumour necrosis factor (TNF) that destroys cancerous cells but that is also implicated in autoimmune disease.

Researchers in Sweden sought to determine if use of tumor necrosis factor inhibitor drugs to treat RA would result in a reduced risk of acute coronary syndrome (commonly called ACS), defined as a diagnosis of a heart attack or unstable angina (the worsening or increasing cardiac symptoms)

Tumor necrosis factor inhibitor drugs (commonly called Anti-TNFs) modestly reduce the risk of acute coronary syndrome, such as heart attacks and angina, in rheumatoid arthritis patients whose inflammation places them at higher risk of developing coronary heart disease, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in San Diego.

Researchers led by David Wallach of the Weizmann Institute of Science in Rehovot looked more closely at a receptor called p55, which binds to a suicide - promoting cytokine called tumour necrosis factor (TNF).

Researchers from Massachusetts Eye and Ear / Harvard Medical School have identified inflammatory factors that cause optic neuropathy in the back of the eye following implantation of a keratoprosthesis (KPro)-- similar to what glaucoma patients experience, without the rise of pressure in the eye — and have shown that blocking one of those factors, tumor necrosis factor alpha (TNFa), successfully halts the development of optic nerve damage in a mouse model.

They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.

They found that microglia then responded to another protein found in the brain called ψ - interferon by producing free radicals containing nitrogen and a third protein called α - tumour necrosis factor.

In the process they induce inflammation; the cells also secrete other inflammatory chemicals, like interleukin - 6 and tumor necrosis factor - alpha, which are known to adhere to the endothelium of the blood vessels, an early event in atherosclerosiIn the process they induce inflammation; the cells also secrete other inflammatory chemicals, like interleukin - 6 and tumor necrosis factor - alpha, which are known to adhere to the endothelium of the blood vessels, an early event in atherosclerosiin atherosclerosis.

On the other hand, there are patients who do not show any significant improvement even after the second or third biologic drug treatment — typically with TNF inhibitors (which blockade the Tumour Necrosis Factor TNF, which is involved in systemic inflammation).

Of note, several proteins involved in the tumor necrosis factor, or TNF, pathway increased in activity during the induction and execution phases.

In the study, the biomedical engineers killed the cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nodeIn the study, the biomedical engineers killed the cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nodein the lymph nodes.

Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor - alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma.

Takeda K, Hayakawa Y, Smyth MJ, Kayagaki N, Yamaguchi N, Kakuta S, Iwakura Y, Yagita H, Okumura K. Involvement of tumor necrosis factor - related apoptosis - inducing ligand in surveillance of tumor metastasis by liver NK cells.

It is mediated by the inflammatory cytokines interleukin - 1 and tumour - necrosis factor, both of which are produced in high amounts following sustained activation of Toll - like receptor 4 by LPS.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

Yongwon Choi, with Ralph Steinman and others, identifies a new tumor necrosis factor family member TRANCE (later called RANKL), [i] and subsequently demonstrates its role in the immune and bone system, and also in bone - residing cancers such as multiple myelomas.

The human genes for tumor necrosis factor (TNF - alpha), first identified by Lloyd J. Old and Elisabeth A. Carswell in 1975, and LT (TNF - beta) are cloned.

High - dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

Hypothalamic tumor necrosis factor - α converting enzyme mediates excitatory amino acid - dependent neuron - to - glia signaling in the neuroendocrine brain.

Matrix metalloproteinase - 2 contributes to tumor necrosis factor alpha induced apoptosis in cultured rat cardiac myocytes.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

Selective role for tumor necrosis factor - a, but not interleukin - in down - regulation of CYP3A11 and CYP3A25 in livers of mice infected with noninvasive intestinal pathogen.

Defective localization of the NADPH phagocyte oxidase to Salmonella - containing phagosomes in tumor necrosis factor p55 receptor - deficient macrophages.

Phosphorylation of tumor necrosis factor receptor CD120a (p55) by p42 mapk / erk2 induces changes in its subcellular localization.

Ultraviolet - inactivated human cytomegalovirus induces placental syncytiotrophoblast apoptosis in a Toll - like receptor - 2 and tumour necrosis factor - α dependent manner.

Enhanced monocyte binding to human cytomegalovirus - infected syncytiotrophoblast results in increased apoptosis via the release of tumour necrosis factor alpha.

Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism.

A Role for Focal Adhesion Kinase Signaling in Tumor Necrosis Factor - α — Dependent Matrix Metalloproteinase - 9 Production in a Cholangiocarcinoma Cell Line, CCKS1

25: Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D - dependent and tumor necrosis factor - related apoptosis - inducing ligand - dependent manners.

Regulation of the PKCθ - NF - κB axis in T lymphocytes by the tumor necrosis factor receptor family member OX40.

In addition, inflammatory cytokines and transcription factors have also been shown to be upregulated in taurocholate - induced AP in obese zucker rats leading to increased oxidative stress, fat necrosis and isoprostanes levels, as compared to lean controls [7In addition, inflammatory cytokines and transcription factors have also been shown to be upregulated in taurocholate - induced AP in obese zucker rats leading to increased oxidative stress, fat necrosis and isoprostanes levels, as compared to lean controls [7in taurocholate - induced AP in obese zucker rats leading to increased oxidative stress, fat necrosis and isoprostanes levels, as compared to lean controls [7in obese zucker rats leading to increased oxidative stress, fat necrosis and isoprostanes levels, as compared to lean controls [7].

Higher serum levels of pro-inflammatory factors such as interleukin - 6 and tumor necrosis factor are found in aged mice.

Michael Croft, Ph.D., and his team focus on a number of molecules that are members of the tumor necrosis factor (TNF) and tumor necrosis factor receptor (TNFR) family, a group of proteins believed to play important roles in the ability of the immune system to guard the body against harmful microorganisms.