Despite its name, tumor
necrosis factor stimulates the growth and metastasis of some types of cancer.
Not exact matches
Similar to capsaicin, tumor
necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when
stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor
necrosis factor (50).
The activation dynamics of the transcription
factor NF - κB exhibit damped oscillatory behavior when cells are
stimulated by tumor
necrosis factor — α (TNFα) but stable behavior when
stimulated by lipopolysaccharide (LPS).
Antonio Lanzavecchia finds that efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte / macrophage colony -
stimulating factor plus interleukin 4 and downregulated by tumor
necrosis factor alpha.
Tumor
necrosis factor alpha
stimulates killing of Mycobacterium tuberculosis by human neutrophils.
These cells were functionally heterogeneous, produced barrier - protective cytokines, and
stimulated intestinal stromal and epithelial cells via interleukin 17A, interferon gamma, and tumor
necrosis factor.
And according to recent studies conducted in Japan, the full ripe bananas with dark patches on their skin produce the largest quantity of TNF (Tumor
Necrosis Factor), a cytokine that fights abnormal tumor cells in the body by
stimulating the production of white blood cells and assisting their communication.
The numerous flavonoids found in astragalus appear to enhance cell - mediated immunity by increasing the number of T - helper cell type 2 cytokines, increasing levels of tumor
necrosis factor and interleukin - 6, which
stimulates the activity of macrophages, responsible for killing potentially harmful cells.
Aloe also contains high amounts of an immune -
stimulating polysaccharide, especially mannose, which has been shown to induce white blood cells to secrete interferon, tumor
necrosis factor, and beneficial cytokines.
For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids
stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour
necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.
In addition, cancer often
stimulates the liver to make tumor
necrosis factor (TNF).