Specifically, researchers observed a reduction of reactive oxygen species; increase in collagen, which strengthens the fibrous cap; and reduction of the plaque
necrotic core, and these changes were not observed in comparison with the free peptide or empty nanoparticles.
Senior co-author of the study, Andrew Sloan, MD, Medical Director, Brain Tumor and Neuro - Oncology Center at University Hospitals Cleveland Medical Center, observed that GBMs typically have two radiologically distinct regions on MRI: The enhancing mass and
the necrotic core.
Nestled inside is a «
necrotic core,» a graveyard of cells that destabilizes the rest of the plaque and makes it prone to rupture, which can block the artery and cause a heart attack or stroke.