Sentences with phrase «needed drug development»

The results provide desperately needed drug development leads, particularly for agents that target the underlying mutations.

Not exact matches

The computing power needed to model the complex interaction of biological compounds for drug development was not yet readily available, but that was always in the back of Tehrani's mind.

Leerink's bullish Geoffrey Porges expects the big biotech, in bad need of some positive R&D developments after a string of setbacks last year, will use a priority review voucher to hustle this drug to a quick decision at the FDA, which he now expects to arrive before the end of 2017.

At Ionis Pharmaceuticals, we are dedicated to the discovery and development of novel, first - in - class or best - in - class antisense drugs to address significant unmet medical needs in a wide variety of diseases.

«What is clear is that much more needs to be done on the development of drugs policy in the UK as the current situation is both economically and socially damaging,» director Ryan Shorthouse told the Independent.

The funding is provided through the State's Public Housing Modernization Drug Elimination program, part of a modernization program that provides grants to public housing developments where rental income is insufficient and funds are unavailable from other sources for needed repairs and improvements.

Taking antibiotics when they are not needed creates additional health risks as it increases the chance a patient will experience an adverse drug reaction, and also leads to the development of antibiotic - resistant bacteria which affects everyone in the community.

Top among Mazzetti's concerns for the town are maintaining low taxes for residents, increasing awareness about drug use, particularly regarding children and balancing the needs for economic and housing development.

The SAMSHA grant, totaling $ 971,736 over a three - year period, will also support personnel, training and other needs related to the development of a peer mentor initiative to help military veterans enrolled in the County's drug treatment court programs re-adjust to civilian life and get back on track, as well as efforts to increase participation rates in court - mandated treatment programs among justice - involved veterans.

We need more genetic studies and a better molecular understanding of its generation, which could open unforeseen avenues to drug development.»

It also can keep out therapeutic drugs and, when defective, biomolecules that are needed for healthy brain development.

Although these postdocs are active in research, the talk largely centered on moving scientific advances through the complex drug - development process to the marketplace and the clinic — and on the skills and strategies needed to build a career in industry.

«There's a huge, unmet clinical need for new approaches against staph skin infections because of declining antibiotic development and rising drug resistance,» says Lloyd Miller, M.D., Ph.D., associate professor of dermatology at the Johns Hopkins University School of Medicine.

The time it takes for a new drug to go from bench to prescription pad can be staggering — typically three to six years are needed for development before it's even ready for safety and efficacy testing, according to the Pharmaceutical Research and Manufacturers of America.

To find the answers, further study on this difference will be needed to gain a better understanding of susceptibility to disease, efficacy of drugs and even the course of normal development among all individuals, not just between men and women.

The current Ebola virus outbreak in West Africa, which has claimed more than 2000 lives, has highlighted the need for a deeper understanding of the molecular biology of the virus that could be critical in the development of vaccines or antiviral drugs to treat or prevent Ebola hemorrhagic fever.

Editor's note: Several authors during this feature have noted the need to improve the processes used in drug discovery, with the hope that the development of new science talent can contribute to this goal.

Continued support for the development of other novel strategies including drugs, improved case management, insecticides, and new approaches to vector control, is needed before effective dengue control becomes a credible prospect.

Indeed, in this move to secure the foundations of drug development, CRUK has needed to bridge several skills gaps.

This unmet need slows basic research, development of new drug therapies and development of new diagnostic tests to help us detect or treat diseases.

Going forward, the development of a reliable diagnostic kit is much needed to enable hospital, clinic, and public health workers to confirm that patients seeking care are either infected or free of the virus; and while an effective vaccine is being tested, the U.S. Food and Drug Administration should screen existing antiviral medicines to determine if any can protect people from contracting the virus, Song said.

Shurin cautions that at least two years of development will be needed before the first human trials of any drug.

The findings, announced online in the journal Antimicrobial Agents and Chemotherapy and funded by the National Institutes of Health, provide a needed boost to the field of antibiotic development, which has been limited in the last four decades and outpaced by the rise of drug - resistant bacterial strains.

«For drug discovery and development, you need to make variants of lead compounds.

The documentation ranges across the whole spectrum of drug development: Investigators» brochures provide information on all that is currently known about the medicine and so need periodic updating; accurate and concise protocols are required to ensure that trials are performed effectively; clinical trial reports (generally from phase II and III studies) present the information gathered from the trials; higher level documents provide summaries of efficacy and safety data from clinical trial programmes; expert reports provide critical interpretation of the results; and response documents clarify any points that are not clear to the regulatory agencies or provide additional analyses or supporting data for any items of concern.

«We understand where innovations are needed to speed drug development and pursue those ideas.»

That is why in order to be able to advance in the development of more specific and more efficient drugs, the molecular mechanism that regulates the activity of these receptors needs to be deciphered.

Zika infection associated with congenital brain abnormalities is one of the eleven virus diseases that, according to World Health Organization, needs urgent research and drug development attention.

Additional drug development, keeping younger patients in mind, is also needed.

The research field needs to provide evidence of how rhinovirus is harmful to spur such a drug's development as well as to understand which patients would benefit most once such a treatment is available so clinicians can know who should be monitored or treated more aggressively, she said.

While this is hopeful news for some patients, more research is needed to further understand not only IL13RA2, but other molecules in breast cancers that may guide diagnosis, prognosis, and ultimately drug development and therapy.

Drug development efforts based on harmine will need to grapple with its known psychoactive effects on the brain, which may explain its traditional use in spiritual ceremonies and as medicine.

«These findings underscore the intergenerational consequences of drug and alcohol addiction and reinforce the need to develop interventions that support healthy childhood development,» says Prof. Fuller - Thomson.

Commenting on the need for innovative approaches to dementia treatments, Dr Doug Brown, Director of Research and Development at Alzheimer's Society, said: «With no new dementia drugs in nearly 15 years, we're at a critical time for dementia research.

To address the urgent need for therapies, researchers supported by the National Institutes of Health screened a set of 290 compounds already approved by the U.S. Food and Drug Administration or far advanced in clinical development for other indications to determine if any might also show potential for working against MERS - CoV.

Will technology eliminate the need for animal testing in drug development?

The researchers hope that understanding the level of virus needed for transmission of infection will provide a useful reference point for the development of experimental drugs and vaccines and could be used to inform the endpoints for clinical trials evaluating such interventions.

The bottom line on which both the FDA and the IOM agree is that there needs to be better, more transparent tracking of drug safety throughout a product's development, release and use.

Compared with the development of new drugs to treat other diseases, «Alzheimer's drug development is more expensive, takes longer, and needs a larger sample of potential patients,» Lo acknowledges.

Compelling infographics round out this robust examination, illustrating data sets on the costs of developing drugs, the major shifts in global demographics and patient needs, the explosions of data that must be mined for future therapeutic development, and the health spending of a wide variety of nations.

«If these drugs could also be successfully used to treat other diseases, which would save a lot of time and money that are needed for the development and approval of new drugs.»

And with non-melanoma skin cancers being the most frequent human tumors, there is clearly a tremendous need to understand the underlying molecular mechanisms, to allow the development of drugs to treat these types of cancer.

«Expectant mothers with epilepsy may need to continue their drug regime during pregnancy; this research may give them some reassurance that — provided they are prescribed topirimate and levetiracetam — they will a statistically good chance of normal, healthy development in their children,» concluded Dr Bromley.

This method of making larger superparamagnetic crystals paves the way for the development of superparamagnetic bulk materials that can be reliably controlled by moderate external magnetic forces, revolutionizing drug delivery to tumors and other sites in the body that need to be targeted precisely.

During sofosbuvir's development, they had studied other drugs that inhibited different viral proteins and that might eliminate the need for continued use of interferon and ribavirin.

The Biomedical Advanced Research and Development Authority — a U.S. government agency tasked with speeding up the development of emergency drugs and vaccines — recently sent two staffers to Ames to help NewLink file documents needed by the U.S. Food and Drug Administration, a U.S. government representDevelopment Authority — a U.S. government agency tasked with speeding up the development of emergency drugs and vaccines — recently sent two staffers to Ames to help NewLink file documents needed by the U.S. Food and Drug Administration, a U.S. government representdevelopment of emergency drugs and vaccines — recently sent two staffers to Ames to help NewLink file documents needed by the U.S. Food and Drug Administration, a U.S. government representative says.

Lead researcher, Associate Professor Julianne Djordjevic, said she is optimistic this discovery will provide a new avenue for the development of safer urgently needed antifungal drugs.

«More drugs are under development to treat cystic fibrosis and other lung conditions, and improved imaging techniques are needed to test their effectiveness,» Altes said.

Not only does it help establish PsA as a condition in its own right, but it could have major implications in the way that patients with this condition are treated and lead to the development of drugs specifically developed for PsA, which are greatly needed.»

For example, Novartis and the University of Pennsylvania's lead candidate (CTL019) for treating a range of hematological malignancies received breakthrough status from the US Food and Drug Administration (FDA) in 2014, permitting access to an expedited drug development pathway for high unmet medical needs Drug Administration (FDA) in 2014, permitting access to an expedited drug development pathway for high unmet medical needs drug development pathway for high unmet medical needs (1).