«What has been a major puzzle in the CRISPR — Cas field is how Cas9 and similar RNA - guided complexes locate and recognize matching DNA targets in the context of an entire genome, the classic
needle in a haystack problem,» says Samuel Sternberg, lead author of the Nature paper and a member of Doudna's research group.
I think the pool of available partners at this age creates
the needle in a haystack problem.
Not exact matches
«The
problem,» Wong said, «is that trying to find a few molecules
in a liquid medium is like trying to find a
needle in a
haystack.
Adding to the «
needle -
in - the -
haystack»
problem isn't a good use of anyone's time.
The chances of finding that
needle in a
haystack are like a horrible math
problem: If x percentage like our book (enough to buy it) > y percentage who love our book (but not enough to champion it) > z percentage who want to marry our book and have babies with it, then solve for A. I don't know about anyone else, but that gives me a headache.
The
problem is better search capability so you can find the
needle in the
haystack — not to throttle the creation of content.
Clients want the
needle in the
haystack, the lawyer who knows how to solve their precise
problems, and thanks to the Web, clients can find them.