Other projects focus on studying how mutations found in the genes for skeletogenic transcription factors cause skeletal and other defects in human patients and finding ways to overcome
the negative effects of these mutations in patients.
If we can develop therapies that help them fight off
the negative effects of the mutation, we're hopeful that people could expect more healthy years, thanks to the remarkable ability of the brain to cope with damage.
Not exact matches
But such
mutations would be less
of a blow, and thus more likely to be passed on to future generations, if their
negative effects arose only after a woman was old enough to have done most
of her reproducing.
By slightly changing these master genes, evolution could have an outsized
effect on overall expression without as much chance
of negative mutations, Gilad says.
«These
mutations have been with us for thousands, or in some cases hundreds
of thousands
of years, passing from one generation to the next, because until now our diet didn't trigger any
negative effects.»
«The initial idea was to determine the DNA sequence
of patients with autism, for instance, find the one or two mutated genes that cause the disease, and develop drugs to overcome the
mutations»
negative effects,» explained Krogan.
The
negative effects of the rapid introduction
of new genetic traits on the health have been best documented in the «The Rare Color Bulldog Craze».17 Indeed, English bulldog breeders appear to be more interested in adding recessive coat color
mutations to increase puppy value than eliminating known deleterious
mutations.