In this regard, insecure attachment styles have received theoretical attention [7] as well as some initial empirical support [8 — 10] as mediators between childhood adverse experiences and both positive and
negative psychotic features; however, further specificity needs investigating.
Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that NMDAR antagonists, the dissociative anesthetics, could replicate the full range of
psychotic,
negative, cognitive, and physiologic
features of schizophrenia in normal subjects that placed the «NMDAR hypofunction hypothesis» on firm footing.