Sentences with phrase «neoadjuvant therapy»
Neoadjuvant therapy refers to a type of treatment, usually used for cancer, that is given before the main treatment, such as surgery or radiation therapy. It is used to shrink the tumor and make it easier to remove or treat. Full definition
Loibl and colleagues investigated whether the presence of a PIK3CA mutation affected patients enrolled in the GeparSixto (G6) clinical trial in experiencing a pathologic complete response after neoadjuvant therapy.
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In some women with breast cancer treated with neoadjuvant therapy, no residual invasive cancer can be detected in breast tissue samples and lymph nodes removed during surgery.
«In an era of increasing use of minimally invasive surgery that enables administration of adjuvant therapy more reliably,» says Dr. Yendamuri, «the paradigm of routine neoadjuvant therapy for patients with this stage of disease should be reconsidered.»
Ecker BL, Paulson EC, Datta J, Jeganathan AN, Aarons C, Kelz RR, Mahmoud NN: Lymph node identification following neoadjuvant therapy in rectal cancer: A stage - stratified analysis using the surveillance, epidemiology, and end results (SEER)- Medicare database Journal of Surgical Oncology 112 (4): 415 - 420,2015.
The work that garnered the honor, «An analysis of the risk and benefit of neoadjuvant chemotherapy among patients undergoing surgery for non-small cell lung cancer,» examined data from more than 134,000 patients in the National Cancer Database to assess the impact of neoadjuvant therapy on perioperative outcomes, as well as long - term survival.
«We found that very few women with HER2 - and hormone receptor - positive breast cancer with a PIK3CA mutation experienced a pathologic complete response after receiving neoadjuvant therapy.
«To evaluate these findings in a group with only one HER2 treatment, we are currently analyzing data from another clinical trial, the GeparQuinto clinical trial, which is a randomized, phase III clinical trial evaluating two different neoadjuvant therapy regimens with a single anti-HER2 treatment [trastuzumab or lapatinib] for women with HER2 - positive breast cancer,» said Loibl.
Treatment given to shrink or eliminate a tumor before surgery is called neoadjuvant therapy.
«We also need to integrate PIK3CA mutation analysis of breast tumors into routine practice so that we can ensure women receive the most appropriate neoadjuvant therapy for their tumor type.»
A drawback of this approach is that determining whether neoadjuvant therapy has done its job can only happen via tumor - tissue analysis following surgery.
Known as neoadjuvant therapy, systemic treatment prior to surgery is often an option for some other cancers, such as breast, in early stages but was not available for melanoma patients until recently because of the lack of treatments with favorable response rates.
The analysis found that patients who underwent neoadjuvant therapy had slightly higher 30 - day and 90 - day mortality without providing a survival advantage among patients whose cancer had spread to their lymph nodes.
SLNB is commonly used following neoadjuvant therapy, but evidence has suggested that many women may not have any residual disease in the lymph nodes at this point.
Following surgery, adjuvant therapy will consist of up to 12 months of atezolizumab in participants who demonstrate clinical benefit with neoadjuvant therapy.
Neoadjuvant therapy will consist of two 21 - day cycles with atezolizumab.