Conical expansion of the outer subventricular zone and the role
of neocortical folding in evolution and development.
In its trial runs Markram's Blue Gene has emulated just a single
neocortical column in a two - week - old rat.
We demonstrate that the spiking activity of single
neocortical neurons in the somatosensory cortex of the rat can be used to decode patterned tactile stimuli delivered to the distal ventral skin of the second forepaw digits on both sides of the body.
Polleux F., Dehay C., Moraillon B. and Kennedy H. (1997) Regulation of neuroblast cell - cycle kinetics plays a crucial role in the generation of unique features of
neocortical areas.
The UAB researchers, led by corresponding author John Hablitz, Ph.D., professor and interim chair of Neurobiology, UAB School of Medicine, found that treatments that inhibit DNA methylation in cultured
rat neocortical neurons caused an increase in the IME of those neurons, as shown by an increased frequency of a series of action potentials when the neurons were stimulated.
Therefore, aRG cells serve both as neural stem cells and as tracks for neuronal migration, positioning them at the very centre of
neocortical development.
Reduction of frontal
neocortical grey matter associated with affective aggression in patients with temporal lobe epilepsy: An objective voxel by voxel analysis of automatically segmented MRI
In the new study, led by graduate student Steven Briscoe, the team found that other populations of neurons in the bird DVR share molecular signatures
with neocortical intratelencephalic cells, or IT neurons.
For example, ancestral limbic systems mediate «long term» memory, i.e., meaning and experiential relations, whereas later
evolved neocortical zones mediate the discriminant perception of external objects, i.e., the analysis of mental objects into (external) space.
The schism provides space
for neocortical justification (doctrine) of its violation of our limbic sense of love, good, and justice.
They help communicate between
different neocortical layers and across cortical areas from one side of the brain to the other.
«These results enable us to demonstrate that the long - term,
neocortical traces of memory are formed right when the information is first gathered,» says Dr. Monika Schönauer, who supervised the study.
Attachment does not live in the stomach, where the early psychoanalysts tried to put it; nor does love live in the lexical, rational,
neocortical brain, where the philosophers and theologians try to put it.
«The first goal is to understand this
[neocortical] column,» he says.
There was not enough evidence to make a recommendation for people with
temporal neocortical epilepsy or temporal tumors.
Markram's laboratory has characterized the electrical properties of
many neocortical neuron types through experiments in vitro, and constructed a model for each.
To answer this question of nature versus nurture, the researchers took cells that would grow to become chandelier cells in the hippocampus and transplanted them into the neocortex, and took cells that would grow to
become neocortical chandelier cells and transplanted them to the hippocampus.
We first focused on SRGAP2 and its human - specific paralogs because we previously reported that this gene plays important roles
during neocortical development, in particular regulating neuronal migration and dendritic branching (Guerrier et al., 2009).
Host: Dr. Tim Murphy Speaker: Dr. Eilif Muller, Blue Brain Project, Switzerland Title: Reconstruction and Simulation of Neocortical Microcircuitry
The relationships of the «primary»
cytoarchitectonic neocortical fields, 17, 41, 3b, and 4 (Brodmann areas), to salient topographic landmarks have been reconstructed from serial histological sections
Changes in prefrontal activity during improvisation were accompanied by widespread activation of
neocortical sensorimotor areas (that mediate the organization and execution of musical performance) as well as deactivation of limbic structures (that regulate motivation and emotional tone).
The ways that we
form neocortical assemblies behind the things we remember, where a whisper of a perfume or a few notes of a song can trigger recall of the entire memory.
After decades of cognitive and behavioral scientists purposely seeking «to put emotions out of sight and out of mind,» says neuroscientist Jaak Panksepp, they're being forced to «relearn that ancient emotional systems have a power that is quite independent of
neocortical processes.»
Neocortical grey matter distribution underlying voluntary, flexible vocalizations in chimpanzees.
The article, «Artificial spatiotemporal touch inputs reveal complementary decoding in
neocortical neurons «unveils central brain mechanisms for touch with widespread applications for neuroprostheses design and understanding neurological disease.
It is called «Bilateral tactile input patterns decoded at comparable levels but different time scales
in neocortical neurons» and investigates to which extent individual neurons of the primary somatosensory can decode contralateral and ipsilateral input.
The cascade of whole / part shifts over evolutionary growth planes in the brain leads from a core in upper brainstem through limbic formations to
the neocortical rim.
With this computer, Markram has created a preliminary model of
a neocortical column — a set of about 10,000 cells that work together — equivalent to one in the brain of a 2 - week - old rat.
You are modeling not a human brain or a monkey brain but something very specific —
the neocortical column in a two - week - old rat.
And
the neocortical column is the elementary processor for human beings to have coherent perception, attention, and memory.
The scientists, in collaboration with IBM, are launching the effort by building a computer model of
the neocortical column of a rat, a single circuit of about 10,000 cells, each of which is capable of thousands of connections.
Since the current work was done in mice, O'Leary and Zembrzycki want to confirm the link in humans by using brain scans to measure the natural variation in
the neocortical areas and search for potential links to disease.
One year into the project, a simulation of
a neocortical column is already in place.
«
The neocortical expression of this gene was most likely lost in a common ancestor and reappeared in the human lineage,» Sousa said.
The aim of the Blue Brain Project is to build a replica of
a neocortical column, the basic functional unit that makes up the cerebral neocortex while encompassing most of the neocortex's cellular diversity.
Additionally, the hippocampal chandelier cells were born several days earlier during embryonic development than
the neocortical ones.
Lastly, the team identified a gene, calretinin, in the hippocampal cells which was not expressed in
the neocortical cells — suggesting the possibility that these cells exhibit different functional properties as well.
While there's been some research looking at how
the neocortical surface of primates has increased over time, practically nothing prior to this has been done on rodents.