Previous attempts to maintain cultures of the so - called
nephron progenitor cells often failed, as the cells died or gradually lost their developmental potential rather than staying in a more medically useful precursor state.
This is a reconstitution of glomeruli by propagated
nephron progenitors derived from human iPS cells.
Not exact matches
The researchers then used a 3 - D cell culture system to coax their mutant and healthy hPSCs down the differentiation pathway into becoming kidney
progenitor cells and finally the proximal tubule cells found in kidney
nephrons.
Next, the researchers would like to investigate how to culture the other types of
progenitor cells that are required for a full kidney, in addition to the
nephrons formed by NPCs.
A paper on the work, «Prostaglandin signaling regulates
nephron segment patterning of renal
progenitors during zebrafish kidney development,» was published in the journal eLife this week.