Sentences with phrase «nerve cell damage»

Scientists from Harvard Medical School have identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis, or ALS, a progressive and incurable neurodegenerative disorder.

As a result, the mice failed to show the type of progressive nerve cell damage seen in MS.

The findings could open the door for new therapeutics designed to help repair nerve cells damaged by neurodegenerative disease.

Working with Tanz researcher Tetsuro Murakami and with colleagues at the University of Cambridge and Columbia University, they focused initially on the FUS protein, and discovered that these abnormal clumps could actually be a very important player in causing nerve cell damage and ALS.

«When glucose utilization is impaired in neurodegenerative diseases, transport of KBs [ketone bodies] into the brain appears to be less affected and their utilization for energy by the brain mitochondria is not impeded by such factors as local insulin resistance that, by interfering with the neuronal fuel supply, may contribute to the progressive nerve cell damage observed in Alzheimer's disease» (1).

Lion's mane mushroom is proven to increase NGF, which happens to be the exact neuropeptide needed to prevent nerve cell damage

In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirely.

Many researchers think that breakdown is driven by the body's immune system: Immune cells flock to the brain, causing inflammation and myelin destruction, which leads to continued nerve cell damage.

Because most if not all people with MS experience nerve cell damage, researchers have begun to focus on two organelles within the neuron's cell body: the power - generating mitochondria and the labyrinth - like endoplasmic reticulum, which makes many of the proteins, lipids and other molecules needed by the cell.

Other scientists have shown that tamoxifen and similar drugs might also reduce nerve cell damage in the spinal cord and brain.

One such treatment is already under development for testing in humans after the current study showed it stopped nerve cell damage in mice with ALS.

Researchers back then found that exposure to aluminum caused rabbits» brains to develop nerve cell damage — thought to be a precursor to Alzheimer's at the time — and long - term dialysis patients with high levels of the metal developed dementia.

In order to identify abnormalities like nerve cell damage and overall brain shrinkage related to Alzheimer's disease, it is necessary to know what a normal elderly brain should look like.

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

Lion's mane mushroom is proven to increase NGF, which happens to be the exact neuropeptide needed to prevent nerve cell damage (5).

Since Lipton's group co-discovered the SNO reaction some 20 years ago, scientists have linked the reaction to protein misfolding and nerve cell damage in cases of Alzheimer's, Huntington's, amyotrophic lateral sclerosis (ALS / Lou Gehrig's disease) and Parkinson's disease, as well as heart / cardiovascular disease and cancer.

«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.

Nerve cells damaged in diseases such as multiple sclerosis (MS), «talk» to stem cells in the same way that they communicate with other nerve cells, calling out for «first aid», according to new research from the University of Cambridge.

A series of six cell culture assays was designed to mimic multiple old - age - associated pathways of central nervous system (CNS) nerve cell damage, and drug candidates were required to show efficacy in all of these assays before being moved forward into animals.

Researchers in the laboratory of Gladstone Investigator Katerina Akassoglou, PhD, have identified in animal models precisely how a protein that seeps from the blood into the brain sets off a response that, over time, causes the nerve cell damage that is a key indicator of MS.. These findings, which are reported in the latest issue of Nature Communications, lay the groundwork for much - needed therapies to treat this disease.

Whenever it hits the news there's a lot of interest, and recently cannabis found the spotlight again with videos claiming it can reverse the nerve cell damage in Huntington's disease.

Prior research had developed a number of new compounds making use of a novel drug discovery paradigm which begins with natural products extracted from plants; it then entails selecting synthetic derivatives which demonstrate efficacy in multiple assays testing protection against different factors of the nerve cell damage and death which take place in brain injuries and in age - associated neurodegenerative conditions.

There are almost a hundred side effects listed by the FDA, including depression, anxiety, schizophrenia, memory loss, nerve cell damage, Alzheimer's, migraines, reproductive disorders, brain lesions, weight gain, food cravings, seizures and more.

Parkinson's Disease (PD) is a progressive neurological condition generally indicated by nerve cell damage and cell death.

Common types of head injuries include traumatic brain injuries, tears of the brain, skull fractures, scalp injuries, concussions, nerve cell damage and blood swelling between the brain and the skull.