Zigmond asked his graduate student, PhD candidate Jane Lindborg, to look for clearance of
nerve cell debris in these mice.
The mystery Lindborg had to solve was how
nerve cell debris is cleared in these mutant animals,» Zigmond said.
Not exact matches
Without neutrophils,
nerve cells could not properly clear
debris.
Immune
cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear
debris, clearing the way for
nerve regeneration after injury.
Previous studies have pointed to immune
cells called macrophages as the primary immune
cell responsible for engulfing and breaking down
nerve debris.
In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune
cells — neutrophils — can clean up
nerve debris, while previous models have attributed
nerve cell damage control to other
cells entirely.
«We came up with a list of potential cellular candidates that could be compensating for the loss of these specific macrophages and used several different tests to determine which
cells were clearing away the
nerve debris after injury,» Lindborg said.
The gene in question, apolipoprotein E (apoE), codes for a protein in the brain's astrocyte
cells that seems to help spur
nerve cell growth and clear up
debris from neuronal injuries brought by head trauma, stroke, or cerebral hemorrhage.
The study showed that a peripheral
nerve injury in rats sends a message from damaged
nerve cells to spinal cord immune
cells known as glial
cells, which normally act as «housekeepers» to clear out unwanted
debris and microorganisms.
The onset and progression of disease in inherited ALS is determined by the motor neurons and microglia, small immune
cells in the spinal cord, which migrate through
nerve tissue and remove damaged
cells and
debris.