The mice were also injected with a dye that could illuminate the footprints of new
nerve cell growth in the brain.
Intermittent fasting may also promote
new nerve cell growth, which can positively affect cognitive function.
Reports in 2013 and 2014 concluded that GDF11 levels in blood decline with age; restoring the protein in old animals could reverse some heart problems, improve muscle strength and
spur nerve cell growth in the brain.
But because these results had never been duplicated in primates, the
additional nerve cell growth was thought to be a feature peculiar to the rodent brain.
(9) Methylcobalamin may exert its neuroproductive effects through enhanced methylation, acceleration
of nerve cell growth, or its ability to maintain already healthy homocysteine levels.
The gene in question, apolipoprotein E (apoE), codes for a protein in the brain's astrocyte cells that seems to help
spur nerve cell growth and clear up debris from neuronal injuries brought by head trauma, stroke, or cerebral hemorrhage.
Engaging in physical activity increases blood flow and oxygenation in the brain, boosting neural connectivity and
stimulating nerve cell growth in the hippocampus, the center of learning and memory.
But this study hints that the rest periods between bouts of dieting, not the time spent cutting calories, may play an important role in
nerve cell growth in mice, says Mark Mattson, a neuroscientist at the National Institute on Aging in Baltimore, Md., who wasn't involved in the study.
Previous research had indicated that a protein known as insulin - like growth factor - 1 (IGF - 1), which stimulates
nerve cell growth, was a good therapeutic candidate for ALS, but trials in which it was administered directly were not successful.
He also filled the glass electrode casing with a proprietary mix of nerve growth factors — proteins that spur
nerve cell growth — to encourage axons to grow into the electrode, thereby holding the device snugly in place and also bringing the neural signals inside, close to the electrode wires.