Aguirre, J.A.; Kehr, J.; Yoshitake, T.; Liu, F.L.; Rivera, A.; Fernandez - Espinola, S.; Andbjer, B.; Leo, G.; Medhurst, A.D.; Agnati, L.F.; Fuxe, K.
Protection but maintained dysfunction of nigral dopaminergic
nerve cell bodies and striatal dopaminergic terminals in MPTP - lesioned mice after acute treatment with the mGluR5 antagonist MPEP.
Prior research had developed a number of new compounds making use of a novel drug discovery paradigm which begins with natural products extracted from plants; it then entails selecting synthetic derivatives which demonstrate efficacy in multiple assays testing
protection against different factors of the
nerve cell damage and death which take place in brain injuries and in age - associated neurodegenerative conditions.