We can get new
nerve cells from a patient's own eye.
Not exact matches
The study, published Feb. 5 in Nature Neuroscience, showed that the
patients»
nerve cells — converted directly
from patients» skin
cells — exhibited «symptoms» of the disorder, including DNA damage, dysfunctional mitochondria and
cell death.
So far, researchers with the Allen Institute for Brain Science in Seattle have described the intricate shapes and electrical properties of about 100
nerve cells, or neurons, taken
from the brains of 36
patients as they underwent surgery for conditions such as brain tumors or epilepsy.
Another approach might be to selectively remove CD11b leukocytes
from the blood circulation so that they are not available to adhere to the blood -
nerve barrier endothelial
cells in
patient's
nerves.
Nerve cells extracted
from a
patient's own nose could one day be used to cure paralysis.
Developing safe and effective therapies for conditions such as peripheral
nerve disorders requires the ability to take investigations
from cells in a petri dish to
patients in a clinic.
Now Ahern has discovered that some drugs used to put
patients to sleep may also increase postoperative pain
from the procedure itself by boosting the activity of a protein called TRPA1 on the surface of pain - sensing
nerve cells.
By examining the
cell cultivation dishes, the researchers were able to observe how the
patients»
cells behaved and developed
from stem
cells to
nerve cells and compare them with
cells from healthy controls.
During an early clinical trial at the Miami Project last year, researchers took Schwann
cells from an easily accessible sensory
nerve in a
patient's leg, grew them in culture and injected them at the point of the spinal cord injury.
The researchers, led by University of California, San Diego neuroscientist Mark Tuszynski, took skin
cells from the
patients, grew them up in a culture dish and genetically engineered them to make human
nerve growth factor (NGF).
Easily accessible
from nasal biopsies, these
cells — which belong to
nerve tissues and can differentiate into neurons — constitute an interesting model to identify the genes and proteins whose expression is deregulated in
patients with ASD.
Alterations in the genetic coding for a
nerve cell receptor, which detects a chemical signal that is key to behavioral change, could point the way to designing therapies most effective for
patients suffering
from schizophrenia, drug addiction and other mental illnesses.
The evidence
from the
patients examined by Rice and Bowsher suggests that the
nerve cells also act as an additional sensory system.
The pattern of RGC loss in
patients as well as information obtained
from laboratory research all point to the fact that an important site of pathology occurs at the optic
nerve head, a region where the axonal
cell processes of RGCs exit the eye on their way to the visual centers of the brain.
Using flourescence imaging, the scientists tested calcium response (an important nervous system ion implicated in the symptoms of bipolar disorder) in olfactory
nerve cell samples
from 17 bipolar
patients (10 currently taking medication, 7 medication - free) with those of matched controls.
«This technology should allow us to very rapidly model neurodegenerative diseases in a dish by making
nerve cells from individual
patients in just a matter of days — rather than the months required previously,» said Dr. Lipton.
It is now almost routine to grow skin
cells from a
patient with, say, a neurological disease; turn them into pluripotent
cells in a Petri dish; convert the
cells into
nerve cells to study the disease process; and contemplate using the
cells to repair the same
patient's damaged brain.
MS
patients could benefit
from the increased energy supply to the brain, which also results in improved
nerve cell protection.
Dr. Olby wants to restore the myelin sheath to these surviving axons by taking fat
cells from the
patient and turning them into stem
cells that can be combined with
nerve cells and injected into the site of the damage, regrowing the sheath.