Imagine how difficult it is for a patient and their family and friends when they lose vision, as is the case in a disorder such as age - related macular degeneration (AMD), where the unexpected sprouting of weak and leaky new blood vessels leads to death the ath of
the nerve cells of the retina.
Final Report Summary: Glaucoma is a silent disease that, over time, kills
the nerve cells of the retina leading to irreversible blindness.
Not exact matches
Did it started off as a mass
of white ball, then it slowly started developing
nerves,
retina, a cornea, and essentially a complex apparatus for capturing light and transmitting it via
nerve cells to the brain?
That light goes through the transparent liquid behind the lens and strikes the
retina, a thin film
of light - sensitive
nerve cells that line the back
of the eye.
Blind Spot A layer
of nerve cells coats the innermost surface
of the
retina.
Johns Hopkins researchers have developed a method to efficiently turn human stem
cells into retinal ganglion
cells, the type
of nerve cells located within the
retina that transmit visual signals from the eye to the brain.
These electrodes pulse to stimulate
cells in the
retina, transmitting visual information along the optic
nerve to the brain, creating the perception
of patterns
of light.
The impulse starts with excitation
of the left
retina, then travels down the optic
nerve to
cells in the midbrain and brain stem, which excite neurons near both eyes that cause the pupils to constrict.
The
nerve cells of the central nervous system (CNS), which is composed
of the spinal cord, the brain, and the
retina, must be supplied with sufficient oxygen and nutrients through the blood vessel system during development and their subsequent function.
When a rod
cell in the
retina absorbs light, a cascade
of reactions results in a
nerve signal.
Their focus is the
retina, the thin tissue in the back
of the eye containing the photoreceptors and
nerve cells.
In fact, so much
of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the
retina from degeneration, regenerate optic
nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion
cells with self - therapies that completely rebuild the optic
nerve.
The third promising biomarker involves imaging
of the inner
retina, including vascular,
nerve fiber and ganglion
cell components.
This research points to exciting new possibilities for preventing or reversing the disabling vision loss caused by age - related macular degeneration, diabetic retinopathy, retinitis pigmentosa, glaucoma, and other diseases that damage the
retina, the layer
of light - sensitive
nerve cells that line the back
of the eye.
On the surface, the disease appears relatively simple, with high pressure (intra-ocular pressure, or IOP) within the eye associated with the death
of cells in the
retina and optic
nerve dysfunction.
But biopsying tumors in the
retina, the thin layer
of nerve cells in the back
of the eye, risks spreading cancer by unleashing tumor particles into the rest
of the body and the brain.
Layers
of the
retina: RPE, retinal pigment epithelium; PR, photoreceptors; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion
cell layer; NFL,
nerve fiber layer.