The company's products include Avance
Nerve Graft, AxoGuard Nerve Protector and AxoGuard Nerve Connector.
These patients were already candidates for standard DBS and agreed to undergo
the nerve graft after being informed of the risks and benefits.
In the current study, Yu - Shang Lee, PhD, of the Cleveland Clinic, together with Jerry Silver, PhD, of Case Western Reserve Medical School, and others, used a chemical that promotes cell growth along with a scar - busting enzyme to create a more hospitable environment for
the nerve graft at the injury site.
Because the patients in the trial were already candidates for DBS, their insurance pays for all of the routine procedure (excluding the costs associated with
the nerve graft).
Furthermore,
the nerve graft procedure uses existing technology and didn't require development of expensive new tools.
So far, five Parkinson's patients have undergone the combined DBS -
nerve graft procedure, out of six allotted spaces in the trial.
Apart from limited
nerve grafts, doctors have only been able to use synthetic conduits (interposition graft), to reconnect severed nerves so that the nerve fibres can grow back together.
This might allow skin and long, thin
nerve grafts to be grown in the lab.
«Some groups have shown that
these nerve grafts help in the function of the animal,» she says.
For decades, scientists have experimented with using
nerve grafts as a way of bridging the spinal cord injury site in an attempt to recover lost function following spinal cord injury.
Not exact matches
The guide was then implanted into the rat by surgically
grafting it to the cut ends of the
nerve.
They were able to do so by building on an experiment showing that
grafting a peripheral
nerve into the space between a severed spinal cord in an animal model brought about
nerve regeneration (albeit limited).
The
nerve tissue is obtained and implanted during DBS surgery, which means that the patients do not need an additional surgery for the
grafting procedure and still receive all the benefits of the DBS therapy.
A study published in Cell last year demonstrated that human and rat stem cells could be
grafted onto the spinal cord of paralyzed rats, forming new
nerves capable of communicating across the injury site.
The current standard of care, called an autograft, involves surgically removing a less important
nerve, like the one running down the back of the calf, and
grafting it into the damaged area.