The researchers also found that these brainy animals had an adaptive evolution of
their nervous system genes, proving that quality and not just quantity is important.
Not exact matches
The companies» R&D will focus on on a
gene mutation present in a wide swath of patients with ALS, a degenerative
nervous system disease that eats away at nerve cells and weakens muscles.
Mutations are indeed not, so far as we know, selected by any overall purpose favoring evolution; but this is compatible with there being short - run and very naive purposes, desires, or feelings in the atoms and molecules constituting the
genes, as well as in every cell and every metazoan with a
nervous system.
Most vegetables are rich in magnesium which regulates the
nervous system, maintains our
genes, contributes to the creation of energy and allows the contraction and relaxation of muscles.
Genes related to the serotonin transporter, cardiac channelopathies, and the development of the autonomic
nervous system are the subject of current investigation.44 The serotonin transporter recovers serotonin from the extracellular space and largely serves to regulate overall serotonin neuronal activity.
It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel
genes that result in long QT syndrome as well as in other
genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel
gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in
genes pertinent to the embryologic origin of the autonomic
nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.
A large number of
genes involved in
nervous system development and function were also deregulated.
«While these findings are specific to HD and PD, these two diseases are sufficiently distinct to suggest that the observed pattern of differential
gene activity may likely be observed in other neurodegenerative diseases of the central
nervous system, including Alzheimer's disease and Chronic Traumatic Encephalophathy (CTE).»
«Same switches program taste, smell in fruit flies: Findings help explain how complex
nervous systems arise from few
genes.»
However, they determined the blood levels of SMN are not altered when SMN levels are altered in motor neurons using a
gene therapy approach delivered directly into the cerebrospinal fluid to target the central
nervous system.
Several of the network
genes Volkan and her team identified have counterparts in humans and other vertebrates, which suggests the same basic mechanism could be at work in building the
nervous system in other animals too.
The Duke researchers who made this discovery say it may help explain how a relatively small number of
genes can create the dazzling array of different cell types found in human brains and the
nervous systems in other animals.
A team of researchers at the University of Central Florida is using breakthrough
gene - editing technology to develop a new screening tool for Parkinson's disease, a debilitating degenerative disorder of the
nervous system.
«Dogs have more than 20,000
genes with sophisticated immune and central
nervous systems.
The ALK
gene is important during embryonic development of the
nervous system but should be inactive later in life.
The repertoire of active
genes in their livers more closely resembled those of the northern Texas lizards, including
genes involved in the functioning of the
nervous and muscular
systems.
How do brains grow, how do
genes build complicated
nervous systems?
«Although we know about several
genes associated with ASD, a challenge and a major goal has been to find where in the
nervous system the problems occur,» Ginty says.
«Octopus genome reveals cephalopod secrets: First cephalopod genome contains unique
genes involved in
nervous system, camouflage.»
In a study described in the January 28 issue of Nature Neuroscience, the Hopkins team describes this new
gene control mechanism and how it may contribute to Rett Syndrome, a
nervous system disorder affecting mostly girls that causes problems with movement and communication.
Being able to detect and measure the amount of mutant huntingtin present in the
nervous system will be a valuable way of seeing whether the
gene - silencing drug is hitting its target and has the intended effect, lowering the amount of disease causing mHTT protein.
The ELH
genes are expressed, not only in the bag cells, but in an extensive
system of neurons distributed in four of the five ganglia of the central
nervous system.
The study of almost 8,000 families, published today (21 March) in Nature, found for the first time that mutations outside of
genes can cause rare developmental disorders of the central
nervous system.
As the central
nervous system is also a target of AAV vectors, Hélène Puccio and Patrick Aubourg's teams are investigating whether a similar approach using
gene therapy could be as effective for the spinal cord and cerebellum as it is for the heart.
Such a mechanism could turn chemical ephemera — the ebbing and flowing of calcium ions and gentle currents of nitric oxide — into changes in
gene expression and finally into alterations in the «wiring» of the
nervous system.
Over half of the 70
genes code for proteins that are known to regulate development and physiology of the skeletal, cardiovascular, and
nervous system — just the type of
genes predicted to be necessary for driving the development of the giraffe's unique characteristics.
Now, to enable widespread
gene delivery throughout the central and peripheral
nervous systems, Caltech researchers have developed two new variants of a vector based on an adeno - associated virus (AAV): one that can efficiently ferry genetic cargo past the blood - brain barrier; and another that is efficiently picked up by peripheral neurons residing outside the brain and spinal cord, such as those that sense pain and regulate heart rate, respiration, and digestion.
The vectors are customizable and could potentially be used as part of a
gene therapy to treat neurodegenerative disorders that affect the entire central
nervous system, such as Huntington's disease, or to help map or modulate neuronal circuits and understand how they change during disease.
For example, domestication had seemingly altered 13 places near a
gene called SOX2, which helps maintain cells destined to become part of the
nervous system.
In humans, Dscam plays a role in the developing heart, but the
gene lacks the incredible variability seen in insects and so its exact role in setting up the
nervous system is unclear.
Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the
nervous system, have mutations in the ATRX
gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.
Previous work indicated that this
gene likely was involved in central
nervous system development, but its specific roles were unclear.
The company aims to use CRISPR
gene - editing to craft RNA therapeutics that can be delivered into the central
nervous system — clearly a daunting task for most drug makers.
The paper published online this month in Genetics examines a «foraging
gene» humans share in common with the flies, which plays multiple roles and is found in similar places, such as the
nervous system, in the muscle and in fat.
Now they have demonstrated in vivo for the first time that one dose of this
gene injected into the central
nervous system prevents the cognitive decline associated with aging in old animals which were treated at a younger age.
Kuruvilla's lab group — which has been studying the peripheral
nervous system for years — found that abundance of a particular
gene product in Down syndrome puts a brake on NGF's actions in fostering nerve development.
«Research traces cause of organ dysfunction in Down syndrome: Scientists find overload of one
gene hinders peripheral
nervous system.»
Vastly different outcomes, but relatively few
genes regulate the number of rounds of cell division in the
nervous system before calling a halt.
What's more, although sponges lack a
nervous system, they do have many of the same neural
genes as comb jellies.
Huntington's disease is an hereditary disorder of the
nervous system caused by a faulty
gene on chromosome four.
Future inquiry also relates to cephalopod
genes and regulation relevant to the development and functioning of the
nervous system.
The
genes in question are all involved in the production of myelin, which forms the fatty insulation around nerve cell axons that enables efficient communication in the central
nervous system.
A team of international scientists led by Baylor College of Medicine has discovered a novel
gene (CLP1) associated with a neurological disorder affecting both the peripheral and central
nervous systems.
Alexander Pletnev and colleagues at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, and the nearby Walter Reed Army Institute of Research have taken two
genes from West Nile virus that encode proteins that form the outer envelope of the virus, and spliced them into the dengue virus type 4, which does not attack the central
nervous system.
And on page 1693, another team reports further evidence of the action of natural selection in people: A
gene expressed in microglia, immune cells of the
nervous system, produces a protein found only in humans.
Adeno - associated viruses (AAVs) make fantastic
gene delivery vehicles for episomal
gene expression and are particularly useful for
gene delivery to the
nervous system.
Contact: 508-685-3525;
[email protected] Woods Hole, Mass. — Many of the
genes involved in natural repair of the injured spinal cord of the lamprey are also active in the repair of the peripheral
nervous system in mammals, according to a study by a collaborative group of scientists at the Marine Biological Laboratory (MBL) and other institutions.
By evaluating DNA methylation, the researchers discovered differences in
gene networks and
gene expression linked to the central
nervous system and interactions with HIV that appeared uniquely in monocytes of HIV infected study participants with cognitive impairment.
In an announcement likely to stand as one of the biggest breakthroughs in Huntington's disease since the discovery of the HD
gene in 1993, Ionis and Roche today announced that the first human trial of a huntingtin - lowering drug, IONIS - HTTRx, demonstrates that it reduces mutant huntingtin in the
nervous system, and is safe and well - tolerated.
Oligonucleotide probe selection and synthesis — The 1,178
genes comprising the Falk Center for Molecular Therapeutics (FCMT) Rat CNS microarray were compiled from currently available NCBI / EMBL / TIGR rat sequence databases and commercially available central
nervous system (CNS) microarrays (Affymetrix, Santa Clara, CA) and provided representation from greater than 90 % of the major
gene ontological categories [47].