Stephen Davies, a neuroscientist at the University of Colorado at Denver who studies
nervous system regeneration using stem cells, is one of the key scientists working to overcome the obstacles in place.
Not exact matches
Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the
nervous system clear debris, clearing the way for nerve
regeneration after injury.
We believe that they will also lead to the development of a whole new range of therapies for neurodegenerative diseases of the central
nervous system,» explains corresponding author of the study Jihwan Song, professor and director of Neural
Regeneration and Therapy Group at the CHA Stem Cell Institute of CHA University.
These findings, which reported in the Neural
Regeneration Research, propose new insights into the mechanisms underlying the role of ethanol exposure in central
nervous system injuries, and provide a new strategy for treating the consequences of prenatal ethanol exposure.
«We expect that a patient's central
nervous system cells could migrate into the implanted scaffold, adhere to it, grow and contribute to neural tissue
regeneration,» he says.
Such combined approaches may represent a valid therapeutic strategy to facilitate
regeneration in the central and peripheral
nervous systems after injury or disease,» Sheng says.
«Maybe it's not surprising that a highly evolved central
nervous system wound response, such as scar formation, would play a crucial beneficial function in both wound healing and axon
regeneration,» he said.
In any case, «the traditional hypothesis about the dependence of
regeneration and the
nervous system is also proved in planarians,» concludes, Cebrià.
The new study strengthen the hypothesis suggested about the key role that the
nervous system plays in metazoan
regeneration.
Exceptionally, in the case of newts, a molecule secreted by Schwann cells has been identified; it may explain the participation of the
nervous system in
regeneration.
«Probably, any molecule related to the
nervous systems induce cell proliferation or differentiation during
regeneration,» remarks Francesc Cebrià.
We are further exploring the molecular network in which the Tsc proteins function, and have found that modulation of the growth - promoting mTOR pathway, which is regulated by TSC proteins, can promote axon
regeneration in the adult central
nervous system.
Reconstitution of the central
nervous system during salamander tail
regeneration from the implanted neurospheres.
The resulting astrocytes differed in expression of multiple proteins thought to either promote or inhibit central
nervous system homeostasis and
regeneration.
For example, the zebrafish, a common aquarium specimen, possesses the remarkable ability to rapidly replace damaged and lost body parts including limbs, heart, and
nervous system, making it an ideal model for defining the genetic mechanisms of
regeneration and healing and for identifying drug candidates for use in regenerative medicine.
He has also made fundamental contributions to understanding the role of apoE in the
nervous system, specifically in nerve injury and
regeneration and in the remodeling of neurites on neuronal cells.
The Yale team found more than 580 different genes that may play a role in
regeneration of axons in nerve cells, something that rarely occurs in adult mammals but is of vital interest to scientists hoping to repair injuries to the central
nervous system.