Sentences with phrase «neural cells infected»

Not exact matches

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.

Scientists have revealed molecular differences between how the African and Asian strains of Zika virus infect neural progenitor cells.

Although they show that dengue can infect neural progenitor cells like Zika can, dengue infection does not stunt the cells» growth or lead to cell death.

Using human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).

Both Zika strains were able to infect and cause cell death in neural progenitor cells.

Even though DENV2 infected the cells such as ZIKV, there were no damaging outcomes registered to the neural cells, neurospheres or organoids.

In the present study conducted at IDOR in conjunction with UFRJ, the research team observed that ZIKV infects human - derived iPS neural cells, neurospheres and cerebral organoids causing cell death, malformations and reducing growth by 40 %.

Confocal microscopy of human neural stem cell culture infected with Zika virus (red).

That's consistent with earlier in vitro findings that Zika can infect and damage human neural precursor cells.

A Zika - infected organoid (right) shows collapse of the rosette, with fewer neural stem cells and neurons.

The group employed various viral tracing methods — infecting receptor - expressing neurons with a virus strain and watching them spread as they label infected cells with a fluorescent protein — to visualize the neural circuit downstream of the ESP1 receptor, as well as providing an image of nerve fibers belonging to specific neurons in the brain and synapses relaying impulses from neuron to neuron, to map the anatomical foundation that conveys ESP1 signals in the brain.

Previous research conducted recently in Brazil and elsewhere points to increased mortality rates for human neural progenitor cells (hNPCs) infected by Zika virus, as well as growth inhibition and morphological abnormalities.

«Zika virus infects human neural stem cells.»

One concerning discovery was that the stem cells that Zika was found to infect, called cortical neural precursors, become factories for viral replication.

The approach enabled a wide range of studies of human brain development, including implicating a new class of neural stem cell recently discovered by the lab in the evolutionary expansion of the human brain and identifying how the mosquito - borne Zika virus may contribute to microcephaly in infants infected in utero.

The Zika virus infects a type of neural stem cell that gives rise to the brain's cerebral cortex, Johns Hopkins and Florida State researchers report March 4 in Cell Stem Ccell that gives rise to the brain's cerebral cortex, Johns Hopkins and Florida State researchers report March 4 in Cell Stem CCell Stem CellCell.

In tests using human neural progenitor cells (NPCs)-- self - renewing, multipotent cells that generate neurons and other brain cell types — the scientists found that exposure to sofosbuvir not only rescued dying NPCs infected with the Zika virus, but restored gene expression linked to their antiviral response.

At a later stage, mimicking the second trimester, Zika still preferentially infected neural progenitor cells, but it also affected some neurons.

«If infection occurred very early in development, the virus mostly infected the mini-brains» neural progenitor cells, and the effects were very severe.

According to Tang, three days after exposure to the virus, 90 percent of the cortical neural progenitor cells were infected, and had been hijacked to churn out new copies of the virus.