Sentences with phrase «neural progenitor cells»

In the CNS, transplanted human neural progenitor cells derived from prenatal cortex (hNPCctx) display characteristics important for cell - based rescue of degenerating neurons.

This image shows induced pluripotent stem cell - derived neural progenitor cells after neuronal differentiation.

This is an immunostaining after two weeks of differentiation of neural progenitor cells into neurons.

Regnell CE, Hildrestrand GA, Sejersted Y, Medin T, Moldestad O, Rolseth V, Krokeide SZ, Suganthan R, Luna L, Bjørås M, Bergersen LH (2012) Hippocampal adult neurogenesis is maintained by Neil3 - dependent repair of oxidative DNA lesions in neural progenitor cells Cell Rep, 2 (3), 503 - 10 PubMed 22959434

Cortical neural progenitor cells in turn give rise to immature neurons.

Although they show that dengue can infect neural progenitor cells like Zika can, dengue infection does not stunt the cells» growth or lead to cell death.

Sundberg and colleagues first created induced pluripotent stem cells (iPSCs) from patients» blood cells or skin cells, then differentiated them into neural progenitor cells and finally Purkinje cells.

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.

• Fred Gage and his colleagues at the Salk Institute in La Jolla, California, harvested brain cells from human cadavers and used them to form neural progenitor cells, precursors to adult human brain cells.

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation.

Visual field is preserved in eyes receiving human neural progenitor cell grafts.

, Tata and Ruhrberg discuss cellular and molecular interactions between neural progenitor cells (NPCs) and blood vessels.

They created neural progenitor cells programmed from induced pluripotent stem cells derived from children with ASD.

[1] NT - 020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat.

In this study, we develop a reproducible protocol for efficient reprogramming mouse neural progenitor cells (NPCs) on human foreskin fibroblast (HFF) cells via retroviral transfer of human transcriptional factors OCT4 / SOX2 / KLF4 / C - MYC.

LPA receptors are all over neural progenitor cells, which go on to form neurons and other types of cells in a young brain.

«In combination with synthetic nanoparticles that my laboratory is developing, we may ultimately be able to use these identified miRNAs or proteins to make synthetic exosomes, thereby avoiding the need to use any kind of neural progenitor cell line to induce neuron growth,» said the paper's senior and corresponding author Qiaobing Xu, assistant professor of biomedical engineering at Tufts School of Engineering.

The cells were reprogrammed to become neural progenitor cells able to form functional neuronal networks resembling the developing cortex of the human brain in a dish.

«We discovered that WS neural progenitor cells failed to proliferate due to high levels of cell death,» said Muotri.

«We discovered that neural progenitor cells show properties that can be associated with the disease and were perfectly suitable for use in large - scale drug screens.

The team set up a microscope and video camera over several culture dishes, each containing a single neural progenitor cell taken from a mouse embryo 10 days after fertilization.

Neuroscientists led by Qin Shen and Sally Temple, both of Albany Medical College in New York, wanted to see if the same holds true for vertebrate neural progenitor cells.

When most body cells divide, they give rise to identical offspring, but — at least in invertebrates — neural progenitor cells divide «asymmetrically,» producing two cell types at once.

Individual neural progenitor cells in culture produce different neuron types as time goes by, starting with the innermost cells (green) and followed by more superficial neurons (red).

This indicates that Day 3 represents a previously unrecognized neural progenitor cell stage, Wang said.

The virus is shown in green, vulnerable neural progenitor cells are shown in red, and neurons are shown in blue.

Silvia Prenninger (Calegari, TUD)-- «Unraveling the molecular mechanisms underlying cell cycle progression and differentiation of neural progenitor cells during mouse brain development» (2011)

Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation.

They formed tiny spheres — often called tumor spheres — and expressed proteins typically found in immature neural progenitor cells.

Type 2 Neural Progenitor Cell Activation Drives Reactive Neurogenesis after Binge - Like Alcohol Exposure in Adolescent Male Rats

In summary, eyes receiving human neural progenitor cells retained dramatically better retinal and visual functions compared to control eyes at P100.

Wild type and genetically modified human neural progenitor cells survive for prolonged periods, migrate extensively, secrete growth factors and rescue visual functions following subretinal transplantation in the Royal College of Surgeons rat.

The mechanism by which human neural progenitor cells exert their effects within the retina is not wholly clear, but is likely due in part to growth factor production [39] and possibly also to the manifestation of some RPE - like properties.

Unmodified and transgenic human neural progenitor cells secrete neuroprotective factors in vitro.

For the generation of human iPSCs without viral vectors or genomic insertions, pluripotent factors Oct4 and Nanog were cloned in episomal vectors and transfected into human fetal neural progenitor cells.

The authors transplanted human cortical ‐ derived neural progenitor cells engineered to secrete glial cell line ‐ derived neurotrophic factor (GDNF) into the cortex of a rat model of ALS, where the cells migrated, matured into astrocytes, and released GDNF.

In a quickly executed study that reflects the global public health threat posed by Zika, the researchers compared Zika's effect on cells known as cortical neural progenitor cells to two other cell types: induced pluripotent stem cells and immature neurons.

Scientists have revealed molecular differences between how the African and Asian strains of Zika virus infect neural progenitor cells.

Together with scientists in Vienna they show that disturbance of a very basic biological process, tRNA biogenesis, can result in cell death of neural progenitor cells.

«What's really exciting about this was that the activity differences were detected at a critical time in brain development: when neural progenitor cells are proliferating and expanding in number, just prior to producing neurons,» Silver said.

Spatial visual acuity is preserved in eyes receiving human neural progenitor cell grafts.

In the latest issue of Neuronal Signaling, Tata and Ruhrberg discuss cellular and molecular interactions between neural progenitor cells (NPCs) and blood vessels.

To make the cells, Sundberg first created induced pluripotent stem cells from patients» blood cells or skin cells, then differentiated these into neural progenitor cells and finally Purkinje cells.

Most of these trials involve stem cell - derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

«Strain differences in Zika infection gene patterns: Comparing Asian vs African Zika (or dengue) infection in neural progenitor cells.»

In tests using human neural progenitor cells (NPCs)-- self - renewing, multipotent cells that generate neurons and other brain cell types — the scientists found that exposure to sofosbuvir not only rescued dying NPCs infected with the Zika virus, but restored gene expression linked to their antiviral response.