Sentences with phrase «neurofibrillary tangles pathology»

In addition, neurofibrillary tangles pathology was observed in apes that exhibited plaques and moderate or severe cerebral amyloid angiopathy and in one individual with virtually no amyloid beta pathology.

Not exact matches

Exhaustive brain research has pieced together how extracellular beta - amyloid plaques and intracellular neurofibrillary tangles of tau proteins are strongly linked to the neurodegenerative pathology of Alzheimer's disease.

There is a finely graded inverse association between age and cognitive performance, 3 4 5 but the age at which cognitive decline becomes evident at the population level remains the subject of debate.5 6 7 A recent review of the literature concluded that there was little evidence of cognitive decline before the age of 60.8 This point of view, however, is not universally accepted.5 6 Clinicopathological studies show good correlation between neuropathology and the severity of cognitive decline, 9 10 11 and neurofibrillary tangles and amyloid plaques, the hallmarks of pathology, are known to be present in the brains of young adults.12 13 Emerging consensus on the long gestation period of dementia14 15 also suggests that adults aged under 60 are likely to experience age related cognitive decline.