Sentences with word «neurogenesis»

Spalding KL, Bergmann O, Alkass K, Bernard S, Salehpour M, Huttner HB, Boström E, Westerlund I, Vial C, Buchholz BA, Possnert G, Mash DC, Druid H, Frisén J. Dynamics of hippocampal neurogenesis in adult humans.

«We don't think that what they are identifying as young neurons actually are,» says Arturo Alvarez - Buylla of the University of California, San Francisco, who coauthored the recent paper that found no signs of neurogenesis in adult brains.

Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol.

For example, the existence of adult neurogenesis in humans is still controversial, suggesting that the same benefits seen in mice may not be possible in humans.

Increasing neurogenesis by as much as 100 % returned the adult mice to an «infantlike» state of forgetfulness in the foot shock test and other similar memory tasks, Frankland and his colleagues report online today in Science.

As neurons form rapidly during infancy and early childhood — through a process called neurogenesis — new neurons rearrange connections and destabilize existing memories.

Researchers from Massachusetts Institute of Technology and Tsinghua University in Beijing showed that magnesium promotes neurogenesis in children and also improve cognitive function in adults.

But there is hope: exercise has been shown to stimulate neurogenesis in healthy animals and in people, so Monje thinks there is a good chance that being active would help improve cognition in cancer survivors, too.

These versatile proteins are up - regulated in response to neuronal injury and play a role in the healing process as well as neurogenesis [63, 64].

Like Varamini, his institution lacks an animal facility, so he's now working on neurogenesis in fish.

Rats with decreased neurogenesis were almost twice as likely to relapse, pointing to an interesting connection between learning and memory and addiction.

This highlights a temporal window for potential therapeutic intervention, in order to preserve the beneficial effects of enhanced neurogenesis.

So we decided to test if harmine, an alkaloid with the highest concentration in the psychotropic plant decoction ayahuasca, would trigger neurogenesis in human neural cells,» said Vanja Dakic, PhD student and one of the authors in the study.

How the brain controls DG neurogenesis, dialing it up and down when needed, is a mystery that Song and her team have been trying to solve since Song started her lab at UNC in 2013.

Over the past decade, however, scientists have begun to decipher how neurogenesis occurs and the anatomical location where neural stem cells are born and maintained inside the brain.

«This circuit controls the activity of stem cells in the part of the hippocampus where neurogenesis occurs,» said Song, a member of the UNC Neuroscience Center.

However, increasing neurogenesis after memory formation induced infantile amnesia in these species.

The brain's self - renewal through neurogenesis is impaired in AIDS dementia, Alzheimer's, Huntington's, and other neurodegenerative diseases, as evidenced by a greatly reduced number of aNPCs in brain tissue from individuals suffering from these diseases.

Researchers from several universities in Australia indicate that curcumin, a natural anti-inflammatory and antioxidant, may help reduce symptoms of MDD by restoring neurogenesis and healthy brain function, protecting it from oxidative stress, inflammation, and other types of damage, which could in turn lead to improvements in mood.

Over the past three decades, the field has made important progress in the identification of the molecular mechanisms regulating neurogenesis and neuronal migration of these various classes of cortical neurons.

Using similar techniques, they were able to show that brain aging is due reduce neurogenesis of brain stem cells and that a circulating factor called CCL11 / Endotaxin increase with aging.

It is clear, however, that one of the ways that antidepressants work is by boosting neurogenesis in the hippocampus.

Studies have shown many tantalizing correlations between neurogenesis in the hippocampus and addiction.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

Finally, studies show that swimming can alter the brain via a process called hippocampal neurogenesis which literally means growing new braincells.

«The purpose of such neurogenesis at times when song is stable remains unknown,» the researchers say.

Research from Karolinska Institutet in Sweden suggests that the expression of the so called MYC gene is important and necessary for neurogenesis in the spinal cord.

When it comes to studying neurogenesis in humans, «the devil is in the details,» says Jonas Frisén, a neuroscientist at the Karolinska Institute in Stockholm who was not involved in the new research.

Cai suggested that they could be a result of the hormone's ability to stimulate neurogenesis throughout the brain, which could have cascading benefits throughout the body.

Santhakumar said while researchers who study epilepsy have started to look more closely at how preventing excessive neurogenesis after brain injury could prevent seizures, neuroscientists have traditionally viewed the process as helpful to overall brain recovery.

miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex.

«It has been shown in rodents that antidepressant medication acts by inducing neurogenesis.

Forgetting may also be a downside of adult neurogenesis because the new memories outcompete old memories, notes neuroscientist Jonas Frisén of the Karolinska Institute in Stockholm.

Garthe A, Huang Z, Kaczmarek L, Filipkowski RK, Kempermann G. Not all water mazes are created equal: cyclin D2 knockout mice with constitutively suppressed adult hippocampal neurogenesis do show specific spatial learning deficits.

«It is possible that ongoing hippocampal neurogenesis sustains human - specific cognitive function throughout life and that declines may be linked to compromised cognitive - emotional resilience,» she says.

«Understanding the mechanisms that promote aberrant neurogenesis caused by traumatic brain injury and subsequent seizures may open new therapeutic avenues to prevent epilepsy and associated memory problems caused by impact,» said senior author Dr. Jenny Hsieh, Associate Professor of Molecular Biology and a member of the UT Southwestern Hamon Center for Regenerative Science and Medicine.

With less neurogenesis, the young rodents acted more like adult mice in the experiment.

Acute Psychosocial Stress Reduces Cell Survival in Adult Hippocampal Neurogenesis without Altering Proliferation.

Over the course of their long - term research on so - called young blood, however, the researchers had noted an opposite effect: blood from older animals appears to contain «pro-aging factors» that suppress neurogenesis — the sprouting of new brain cells in regions important for memory — which in turn can contribute to cognitive decline.

Noonan et al overcame this problem by selectively irradiating the hippocampus of rats, inhibiting neurogenesis only in the hippocampus with no effect on the adult neurons or the overall network architecture and function.

He thinks inflammation could be responsible for the lack of new neurons and suggests that perhaps the particular drug that Godbout used didn't have a broad enough effect to restart neurogenesis.

However, the researchers found that stopping neurogenesis before the development of seizures had a long - lasting effect, suppressing chronic seizure frequency for nearly one year, even at a late stage of the disease.

Polleux F., Dehay C. and Kennedy H. (1997) The timetable of laminar neurogenesis contributes to the specification of cortical areas in mouse isocortex.

We measured neurogenesis by counting the number of doublecortin - positive neurons in the dentate gyrus.

With that idea in mind, Neuralstem, in Rockville, Md., has identified a compound that is particularly effective at prompting neurogenesis.

When neurogenesis occurs in the hippocampus (a number of studies have confirmed that this indeed happens), it can lead to significant improvement in memory and learning.