Using similar techniques, they were able to show that brain aging is due reduce
neurogenesis of brain stem cells and that a circulating factor called CCL11 / Endotaxin increase with aging.
Not exact matches
They showed that ZIKV infection
of cortical progenitors (
stem cells for cortical neurons) controlling
neurogenesis triggers a stress in the endoplasmic reticulum (where some
of the cellular proteins and lipids are synthetized) in the embryonic
brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).
This is because larger
brain parts are thought to have a later and longer process
of neurogenesis — the development
of neurons or nerve
cells from neural
stem cells and progenitor
cells.
Whitmer said one theory
stemming from animal research is that metformin may play a role in the development
of new
brain cells (
neurogenesis).
A normally functioning adult human
brain has the ability to partially replenish or repair itself through
neurogenesis, the proliferation and development
of adult neural progenitor /
stem cells (aNPCs) into new nerve
cells.
Molecular mechanisms
of stem cell plasticity and regenerative
neurogenesis in adult zebrafish
brain
We are interested in genetic programs
of neural
stem cells (NSC) in
brain development and postnatal
neurogenesis, and in how NSC misregulation can lead to pathology (hereditary disease, cancer
stem cells).