In dogs totally lacking this protein they are considered to be homozygous for the defect (in their genetic make - up they have 2 genes for the MDRI - l ∆ mutation) and ivermectin a common dewormer and heartworm preventative, in even low doses will induce
neurologic toxicosis.
Pharmacologic treatment with ivermectin, loperamide, vincristine, and other drugs that are substrates of P - glycoprotein, the MDR1 gene product, may result in
neurologic toxicosis in a high percentage of Collies.
Not exact matches
MDR1 - related drug
toxicosis of the CNS often presents as vague
neurologic signs, such as weakness, lethargy, ataxia, and disorientation.