A plane's normal line has no polarity, but each semicircular canal can be rotated in a direction that provides an increase in afferent
neuron firing rate (excitatory direction) or it may be rotated in the opposite direction to produce a decrease in afferent
neuron firing rate (inhibitory direction).
Intrigued by recent findings that
neuron firing rates in the regions of mouse and fly brains associated with visual processing increase during physical activity, UC Santa Barbara psychologists Barry Giesbrecht and Tom Bullock wanted to know if the same might be true for the human brain.
Not exact matches
Different
neurons fired at different
rates depending on what he imagined performing.»
After isolating sensory
neurons from frogs and eels, Adrian showed that as the intensity of a sensory stimulus increases, so does a
neuron's
firing rate, which can peak at 200 spikes per second.
Wolf Singer of the Max Planck Institute for Brain Research, in Frankfurt, supports a code involving synchronous oscillations, or many
neurons firing at both the same
rate and the same time.
In hundreds of trials, the monkeys» reaction times varied from roughly 150 to 400 milliseconds, and the response time depended on how fast the
neurons increased their
firing rate to a level that seemed to trigger the eye movement.
«In the absence of sound,
neurons fire randomly and at a high
rate,» says Burger.
During the day, however, BK channels have little effect on
neuron excitability in the SCN, even though one might expect the increase in neuronal
firing rate to increase BK activation.
Now, scientists have discovered a key component of this ancient navigational system in rats: a group of
neurons called «speed cells» that alter their
firing rates with the pace at which the rodents run.
According to this Mental Synthesis Theory, the subject's brain will trigger an increased
firing rate in both object
neurons and, more importantly, a synchronization of their activities would occur.
«We could stimulate a
neuron to
fire and control the
rate of propagation of the electrical impulse.»
By monitoring the «
firing rate» of each
neuron, they were able to assess which smells elicited the strongest reactions from the flies.
«These results were unexpected and contradicted the current dogma in the field stating that individual
neurons can regulate their own
firing rates in an autonomous manner,» said Dr. Slutsky.
In collaboration with Prof. Eli Nelken of Hebrew University and Dr. Michael Slutsky of Mantis Vision, Slomowitz found that the network returned to its original
firing rate over the course of two days despite the continued presence of the drug — and even though the
firing rates and patterns of individual
neurons did not reflect homeostatic tendencies.
Just as computers use programming languages such as Java, the brain seems to have its own operating languages — a bewildering set of codes hidden in the
rates and timing with which
neurons fire as well as the rhythmic electrical activities that oscillate through brain circuits.
After isolating sensory
neurons from frogs and eels, Adrian showed that as the intensity of a sensory stimulus increases, so does a
neuron's
firing rate, which can peak as high as 200 spikes per second.
Neuroimaging studies showed that such triggers set off an electrical wave of
firing neurons that spread over the occipital cortex at a
rate of several millimeters per minute.
Pramiracetam affects the EEG patterns of aged rats, and increases the
firing rates of acetylcholine - producing
neurons.
When she attached two electrodes to the
neurons — one to stimulate the nerve, the other to record the response — she discovered that the
neurons»
firing rate was abnormally high.
They learned that
neurons in this central location ramp up
firing rates, peaking just before a divergent behavior occurs.
How can changing the
firing rate of the same
neurons in one region lead to different effects on the rest of the brain?
To mimic a learning experience and see how
neurons keep their activity in check, each team tweaked rat or mouse
neurons»
firing rates, genetically or with drugs.
The researchers knew that
neurons fire at a steady
rate to form memories but also that new experiences can overstimulate them.
If - adaptation is strong, such that the
neuron adapts out the increased baseline intensity of the stimulus, then the
firing rate should exceed about as often in the noisy conditions as in the clean condition.
«These R2
neurons have higher
firing rates the more sleep - deprived the fruit flies were and
firing of these
neurons puts flies to sleep, suggesting that we've identified the key cells responsible for sleep drive,» says Wu.
Previous studies in the mouse BACHD model (6 month old), reported an age - dependent increase in mean
firing rate of GP
neurons and decrease in the mean
firing rate of STN
neurons in vitro (D.J. Surmeier, Northwestern Univ.) and in vivo (James Tepper, Rutgers Univ.).
«If we get the timing right, we believe we can decrease the
firing rates of
neurons at the tinnitus frequency, and target those with hyperactivity,» says Shore.
Expression of mutant Htt appeared to alter the
firing rate of STN
neurons, as
firing rates in HET and HOM mice were lower than their WT littermate.
A single bolus IV injection of MP - 10 at all doses studied (0.18, 0.52, and 1.5 mg / kg) produced a clear increase in the
firing rate of STN
neurons in both WT and TG rats.
In the past, people had known that individual
neurons go through phases of being more or less active, but with this probe they saw for the first time that all the
neurons in a given column cycled together between
firing very rapidly then
firing at a much slower
rate, similar to coordinated cycles in sleep.
The
firing rate of STN
neurons appeared to be more sensitive to the presence of mHtt, with lower
firing rates in HET and HOM mice compared to WT counterparts; however there was no change in mean
firing rate difference found for GP
neurons between WT and HET.
The lack of
rate difference in GP could either stem from less sensitivity of GP
neurons to IP dysfunction, or could be due to GP heterogeneity in
firing rate and pattern that makes detection of abnormalities in single unit activity harder in GP than STN.
This shift of perspective invites a change of approach: instead of charting average
firing rates of single
neurons, we must infer behaviorally relevant neural codes from evolving activity patterns across neural populations.
Previously, many researchers had thought that the
firing rate of single
neurons in the prefrontal cortex, the brain's executive, is the major player in working memory.
Again, researchers previously thought that these functions had mostly to do with the
firing rates of
neurons.
Three different activity measures were used to quantify the magnitude of the saccade - related bursts of SC
neurons for movements towards the center of their movement field as a function of their rostral - to - caudal location in the SC motor map: A) number of spikes in the burst, B) mean
firing rate and C) peak spike density.
When the head rotates, inertial drag of endolymph within the duct acts upon sensory hair cells that modulate the
firing rates of primary vestibular afferent
neurons.
Spontaneous
firing rates in Q175Het mice showed a modest increase in both SNr and GP
neurons compared to the WT but did not reach statistical significance.
At any given moment only a few
neurons at any location are actually
firing at any appreciable
firing rate, and so you're representing the world at any given time with a relatively small number of active components.
We demonstrate this intuition by applying three different information - based measures of stimulus encoding to experimental characterizations of sensory
neurons, and demonstrate a transition from «high - slope» to «peak -
firing -
rate» encoding as neuronal variability increases, both for single
neurons and in the context of a small population.
Here, θ0 is the wind direction value that elicits the maximum average
firing rate and differs by 90 ° for each of the four
neurons.
The standard tool in performing this characterization is the neuronal tuning curve: a plot of the average
firing rate of the
neuron as a function of relevant stimulus parameters.
For example, researchers are looking at how inflammation decreases the
firing rate of
neurons in the frontal lobe of the brain in people with depression.