Working with motor neurons derived from ALS patients and healthy controls, Dr. Wainger performed fundamental electrophysiological characterization and identified motor
neuron hyperexcitability in ALS patient - derived motor neurons (Wainger et al., 2014).
Not exact matches
The team found the same
hyperexcitability in the lymphocyte - derived
neurons, validating their earlier results.
The team found that maintaining some people's
neurons in a lithium - infused medium calmed this
hyperexcitability.
Gage and Mertens next plan to follow the affected cells for longer periods of time to see whether the
hyperexcitability they measured is only an initial manic stage of the
neurons» lives or is long - lasting.
«Essentially, they cause acetylcholine to build up in the brain, causing
hyperexcitability of
neurons as well as the death of some
neurons, which leads to inflammation in the brain,» said Ashok K. Shetty, PhD, a professor in the Department of Molecular and Cellular Medicine at the Texas A&M College of Medicine, associate director of the Institute for Regenerative Medicine, research career scientist at the Olin E. Teague Veterans Medical Center, Central Texas Veterans Health Care System and senior author of the paper.
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Hyperexcitability of
neurons and cardiomyocytes in a mouse model of SCN8A epileptic encephalopathy.