Sentences with phrase «neuron model of the disease»

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The researchers, including first author Matheus Victor, PhD, a postdoctoral research associate, set out to generate neurons that would mimic those of adult patients in order to model the onset and progression of Huntington's disease.

The research is also the first to demonstrate beneficial effects of UDCA on dopaminergic neurons, the nerve cells affected in Parkinson's disease, in a fly model of Parkinson's disease which carries the same genetic change as some patients with the condition.

«Novel radiotracer measures olfactory neurons in animal models: Tracking deterioration in sense of smell could provide early diagnosis of neurodegenerative disease.»

Experiments in mouse models of Parkinson's disease and amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease) have demonstrated that Nrf2 - based neural protection is primarily conferred by astrocytes, but how neurons might alert astrocytes to stressful conditions is poorly understood.

The study, published Feb. 16 in PLOS Biology, made use of a mutant zebrafish strain that models human Hirschsprung disease, which is caused by loss of the gut neurons that coordinate gut contractions.

Several laboratories, including one led by Stewart Anderson of the University of Pennsylvania Perelman School of Medicine, have demonstrated that transplanting inhibitory neurons from healthy mice has improved symptoms in mice with models of those diseases.

This Purkinje neuron was derived from patients with tuberous sclerosis and model properties of the disease at the cellular and molecular level.

Our conversion process should model late - onset aspects of the disease using neurons derived from patients with the condition.»

Congratulations to Umrao Monani, Assistant Professor at the Motor Neuron Center of Columbia University and Cathleen Lutz, Associate Director of Genetic Research Science at The Jackson Laboratory, and their colleagues for their new publication «Postsymptomatic Restoration of SMN Rescues the Disease Phenotype in a Mouse Model of Severe Spinal Muscular Atrophy» in the Journal of -LSB-...]

Here, Anna presents how studies of neural stem cells and neurons derived from iPS cells of patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.

The paper «Nav1.1 - Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease» was published online by Neuron on March 15, 2018.

In 2002, the lab proved that transplanting embryonic stem cells in animal models of Parkinson's disease yielded functional new dopamine neurons that restored motor function.

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease

Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.

The experiments, performed in rat models of Parkinson's disease, reveal that the latest version of stem cell - derived dopamine cells fully mimic the characteristics and function of the dopamine neurons that are lost in Parkinson's disease.

Most of the study's experiments were done in the roundworm C. elegans, which have an SMN gene and motor neurons — those that connect to muscle — that are very similar to humans, making them valuable models in which to study this disease.

In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer's.

Because neurodegenerative disorders like PD are largely diseases of aging, modeling them in a culture dish using neurons grown from iPS cells has been thought to be exceedingly difficult, if not impossible.

In the current study, the scientists discovered that, in a mouse model of Alzheimer's disease, the accumulation of tau in neurons disrupts the cells» ability to strengthen their connections with other neurons, preventing them from stabilizing new memories.

Dr. Pfaff has developed a novel embryonic - stem cell - based model of SMA that phenocopies the pathology of human SMA, and can be used to study the basis of the disease and screen for compounds that might increase survival of motor neurons.

The review covers approaches such as spurring the production of new neurons and transplanting new neurons while taking a look at the disease - modeling approaches and techniques that science is now using to refine approaches...

The findings demonstrate similarities in progressive muscle weakness and a decline in motor coordination in both models of motor neuron disease with a later onset and slower progression noted with PFN1 animals.

Using a model of Leigh's disease, a genetically inherited neurodegenerative disorder that affects mitochondria, the researchers tested energy levels in neurons using the new assays.

Working with Ye, postdoctoral fellow Sung - Wuk Jang identified a compound called 7,8 - dihydroxyflavone that can duplicate BDNFâ $ ™ s effects on neurons and can protect them against damage in animal models of seizure, stroke and Parkinsonâ $ ™ s disease.

Using mouse models of MS, Dr. Akassoglou has shown that higher levels of these proteins are early indicators of MS and key contributors to neuron damage, resulting in disease progression.

These are neurons in the eye that respond to decrements in light that we discovered in an animal model are especially vulnerable early stages of the disease.

MIT's Li - Huei Tsai, Ed Boyden, and their colleagues have shown that stimulating neurons to produce gamma waves at a frequency of 40 Hz reduces the occurrence and severity of several Alzheimer's - associated symptoms in a mouse model of the disease.

In a study published in Neuron, Palop and his collaborators uncovered the therapeutic benefits of genetically improving these interneurons and transplanting them into the brain of a mouse model of Alzheimer's disease.

Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high - throughput drug screening.

Jorge Palop and his collaborators discovered that transplanting a special type of neuron into the brain restores cognitive functions in mouse models of Alzheimer's disease.

So for our model of this disease, which we are currently developing, we have to generate a variety of other brain cell types besides neurons that are thought to foster immune responses in the brain.

Neurona's founders have discovered that certain types of neuron transplants can rebalance nervous system activity, repair neural circuits, and rescue multiple animal models of disease.

Duke s research will use patented multielectrode technology to directly measure the activity of hundreds of neurons to study brain dynamics in unique preclinical models of diseases such as Parkinson s and schizophrenia.

For three years now we have been working on human cell models of rare neurodegenerative diseases with special emphasis on neuroacanthocytosis, neuronal ceroid lipofuscinosis as well as motor neuron degeneration (using iPS cells).

DR can protect neurons against degeneration in animal models of Alzheimer's, Parkinson's and Huntington's diseases and stroke.

Multiple studies show that the catechin compounds found in green tea can have various protecting effects on neurons in test tubes and animals models, potentially lowering the risk of disease like Alzheimer's and Parkinson's.

No desirable effect was observed in an animal model of amyotrophic lateral sclerosis (ALS), indicating that intermittent fasting has no beneficial effect on the development of this motor neuron disease (51).

Some phytochemicals which induce the Keap1 / Nrf2 pathway and have demonstrated protective effects in both neuron tissue culture and animal models of Parkinson's and neurodegenerative disease include:

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

D - beta - hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.