Sentences with phrase «neuronal cell replacement»
The findings reveal that NG2 glia represent a promising target for neuronal cell replacement strategies to treat traumatic brain injury.
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Even though it may correct existing neuronal losses, cell replacement is not by itself a cure for HD as it can not stop the progression of the neurodegeneration in the patient's brain.
Ultimately, we use all this information to establish innovative culture techniques for generating unlimited neural stem cell sources for the derivation of specific types of clinically relevant neuronal or glial cells, for their use in disease modelling and drug discovery platforms, and towards refining their efficacy for future cell replacement - based therapy.
Given our extensive experiences in neuronal differentiation of hESCs [6], [7], [8] and the potential application of hESC - derived neurons in cell replacement therapies for neurodegenerative diseases, we designed a set of experiments aimed at developing a hESC - based automated assay for screening small molecules that have differential toxicity to hESC - derived NSCs and their differentiated neural progenies.