Not exact matches
The potential for mind - boosting drugs and technologies has increased stunningly over the past decade as neuroscientists have unlocked the secrets of
neuronal circuits, neurotransmitters, and specific molecular events triggering brain
functions in three interconnected cognitive domains — attention, memory, and creativity.
These findings could be a step in grasping how the brain
circuit is shaped during this early stage development and how these
neuronal circuits contribute to higher cognitive
function in adulthood.
Or we may have developed miniature electronic
circuits capable of monitoring and stimulating neurons, which might be used to augment memory or maintain neural
functions during the replacement of
neuronal nuclei.
One disadvantage with these switch - like approaches is that they can mask more subtle
functions of
neuronal circuits in regulating behaviors.
Jon Storm - Mathisen, Professor of Anatomy at the University of Oslo, and chairman of the Kavli Neuroscience Prize Committee, said: «Major questions in modern brain science are how the complex
neuronal circuits of the brain and spinal cord are assembled during development and how they
function in the adult.
Unravelling the unique contribution of these specific
neuronal populations to the
function of neural
circuits will advance our understanding of how the brain processes abstract cognitive
functions.
This is something that is very difficult to predict, because, of course, if you insert a cell into the
circuit, it should acquire very specific
neuronal identity in order to exert then also specific
functions.
Synapses are essential points of information transfer within
neuronal circuits, and the correct formation and maturation of synapses is necessary for the brain to
function throughout life.
We could, for example, analyze how single neurons
function in a cascade within the
neuronal circuit,» Straw emphasizes the potential of his work.
With this tool, neuroscientists can use light to trigger or suppress
neuronal firing and precisely manipulate animal behavior, allowing them to map
circuits underlying normal brain
functions and study their dysfunction in mood and movement disorders.
In order to analyze the
function of individual proteins in
neuronal circuits or synaptic remodeling, researchers combine the Cre and FLP recombinases to control both knockout of a target gene and expression of a separate gene.
A persistent challenge in unraveling mechanisms that regulate memory
function is how to bridge the gap between inter-molecular dynamics of single proteins, activity of individual synapses and emerging properties of
neuronal circuits.
D melanogaster represents a useful experimental system for analyzing the
functions of
neuronal circuits the results from which can translate to
neuronal function in other organisms, perhaps even including humans.
In his studies, he uses an inter-disciplinary approach and combines physiological, molecular, viral and computational approaches to reveal the structure and
function of retinal
neuronal circuits.
We employ genetic tools in an attempt to understand the contribution of mGluR5 signaling in specific
neuronal populations to sensory
circuit formation, synaptic
function / plasticity, and behavior.
«This allows us to identify subtle changes in the
functioning of
neuronal circuits that we never had access to before.»
Those identified already have been implicated in a variety of
functions, including development of the brain's language
circuits,
neuronal development, signaling, wiring, and synaptic plasticity.