Sentences with phrase «neuronal degeneration»
"Neuronal degeneration" refers to the gradual damage or loss of neurons (nerve cells) in the brain or nervous system. This process can lead to a decline in brain function and potentially result in neurological disorders or conditions. Full definition
«Indeed, even physiological aging is characterized by a progressive decline of motor abilities and patho - anatomic features of neuronal degeneration in the brain, which in many ways are similar to key characteristics of PD (but which do not evoke clinically - relevant signs of PD).»
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I believe that we have a number of insights that provide those of us interested in therapeutic intervention reason to be optimistic about our progress working with diseases of neuronal degeneration, such as Alzheimer's, ALS, and Parkinson's.
A new study to be published in the journal Scientific Reports, describes researchers» investigation into the true culprit for seizure - related neuronal degeneration in epilepsy.
That's crucial, because the memorably named infectious agents, short for porcine endogenous retroviruses, could cause tumors, leukemia, and neuronal degeneration if transplanted into patients.
47: Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E. ESCRT - mediated uptake and degradation of brain - targeted α - synuclein single chain antibody attenuates neuronal degeneration in vivo.
Figure 3B shows that J147 decreases the ratio of pro- to mature NGF in the hippocampus, which is important given that proNGF is elevated in AD brain [66 — 68] and may lead to neuronal degeneration [67].
These findings were important because they provided a link between the physical neuronal degeneration seen in movement disorders, such as Parkinson's, and some of the disease's behavioral aspects.
The result can be impaired thinking, brain fogginess, messed up thought processes, and possible neuronal degeneration.
Little is known about the mechanisms that cause age - related neuronal degeneration and death.
Northwestern Medicine scientists have identified a toxic cascade that leads to neuronal degeneration in patients with Parkinson's disease (PD) and figured out how to interrupt it, reports a study to be published September 7 in the journal Science.
Neuronal degeneration is the most severe long - term consequence of repetitive seizures in patients with epilepsy, which until now was thought to be primarily caused by excitotoxicity, or over-stimulation of the neurons.
«The most obvious function of glial cells has been related to their role in forming scar tissue to prevent the spread of injury and neuronal degeneration, but so much about their role in the brain is unknown.»
«This indicates that the process of neuronal dysfunction which goes on to neuronal degeneration is theoretically rescuable.»
In the study published in the journal Nature Neuroscience, the researchers found that behavioral, cognitive and structural dysfunctions in the new mouse model of ALS and a related disorder, frontotemporal dementia (FTD), were evident long before the neuronal degeneration that occurs late in these diseases.
While enzyme replacement therapy can correct the deficiency in peripheral tissues, researchers have been unable to channel the enzyme across the so - called blood - brain barrier to prevent the accumulation of glucocerebroside in the brain, which results in neuronal degeneration.
«By comparing these diseased neurons with the «genetically corrected» healthy neurons, we could see — cell by cell — how the Tau mutation leads to the abnormal build up of Tau and, over time, neuronal degeneration and death.»
of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.
Analytical endpoints included examination... of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.
Christopher E. Henderson, Ph.D., a neurobiologist specializing in central nervous system development and neuronal degeneration will be joining the institution.
Phosphorylated tau and amyloid plaques, responsible for tau neurofibrillary tangle formation, contribute to neuronal degeneration and dysfunction and Alzheimer's memory loss.
Also, it seems that in the presence of inflammation, tryptophan is not metabolized into serotonin but instead kynurenine and eventually the excitotoxin quinolonic acid, contributing to unoexcitoxicity and neuronal degeneration.