Sentences with phrase «neuronal model cells»

By electrophysiological patch clamp recordings, we probe the response of neuronal model cells to photoexcitation by short light pulses, excluding other pathways than a photoelectrical coupling, to be of passive nature only.

Not exact matches

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

The mouse models of autism on a normal lab diet (with a medium glycemic index) are already known to generate fewer new neurons, and some of their existing cells and neuronal connections are abnormal compared with those of normal mice.

To unravel the complex journey of the body's GPCRs, scientists used biophysical tools, including fluorescent biosensors; biochemical tools, such as cell signaling in neuronal cultures; as well as computational models.

NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals models.

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

He has developed novel cellular models of neurological diseases (schizophrenia, MS, autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor patients and differentiated to specific neuronal cell types.

The retina as a model to explore the cell biology of morphogenesis — from pseudostratification to neuronal arrangements

Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites Kastellakis, G., Silva, A.J., Poirazi, P. Cell Reports.

Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites George Kastellakis, Alcino J. Silva and Panayiota Poirazi Cell Reports (2016) http://dx.doi.org/10.1016/j.celrep.2016.10.015

Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks).

Ultimately, we use all this information to establish innovative culture techniques for generating unlimited neural stem cell sources for the derivation of specific types of clinically relevant neuronal or glial cells, for their use in disease modelling and drug discovery platforms, and towards refining their efficacy for future cell replacement - based therapy.

Zoghbi has also investigated the cell type - specific requirements for MECP2, and recently discovered that restoring MECP2 levels in certain neuronal subsets can rescue Rett phenotypes in mouse models.

Research Interests: Molecular control of cell fate from stemness to differentiated skeletal and neuronal cell types; SOX transcription factors; skeletal malformation and degeneration diseases; intellectual disability and autism spectrum disorders; mouse genetic models; human pluripotent stem cell differentiation models in vitro

There he worked in the Kaplan lab, originally with the Neural Group working to create a scaffold for a model of a three - dimensional interconnected neuronal network grown from human induced pluripotent stem cells.

Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma Buckingham, B.P., Inman, D.M., Lambert, W., Oglesby, E., Calkins, D.J., Steele, M.R., Vetter, M.L., Marsh - Armstrong, N. & Horner, P.J. (2008) Journal of Neuroscience, 28:2735 - 2744.

Silencing WDR47 in hypothalamic GT1 - 7 neuronal cells and yeast models independently recapitulated these findings, showing conserved mechanisms.

For three years now we have been working on human cell models of rare neurodegenerative diseases with special emphasis on neuroacanthocytosis, neuronal ceroid lipofuscinosis as well as motor neuron degeneration (using iPS cells).

51/2: 30 RNA sequencing of a mouse model of spinal muscular atrophy reveals tissue - wide changes in splicing of U12 - dependent introns in genes involved in cell cycle, intracellular trafficking, and neuronal function.

He has studied the role of mitochondrial dynamics in neuronal apoptosis and neurodegeneration, and for the past five years bioenergetics and mitochondrial dysfunction in neurodegenerative disease models and mechanisms of insulin secretion in pancreatic beta cell models.