Neuronal progenitor cells resemble stem cells in that they have the ability to specialize into different cell types, though with a more limited range of differentiation.
Dorian Freudenreich (Brand, TUD)-- «Genetic cell lineage tracing and transcriptome analysis of
neuronal progenitor cells during neurogenesis and regeneration of the adult zebrafish telencephalon» (2010)
Jennifer Fish (Huttner, MPG)-- «The evolution of
neuronal progenitor cell division in mammals: the role of the abnormal spindle - like microcephaly associated (Aspm) protein and epithelial cell polarity» (2007)
Not exact matches
This image shows induced pluripotent stem
cell - derived neural
progenitor cells after
neuronal differentiation.
The
cells were reprogrammed to become neural
progenitor cells able to form functional
neuronal networks resembling the developing cortex of the human brain in a dish.
Progenitors of the central retina are the first to leave the
cell cycle and differentiate into the six
neuronal and one glial
cell class of the mature retina.
NeuroStemcell is focused on the identification and systematic comparison of
progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic
neuronal differentiation, generated either directly from human embryonic stem (ES)
cells, from Neural Stem (NS)
cells derived from ES
cells or fetal brain, from induced Pluripotent Stem (iPS)
cells or from in vitro short - term expanded neural
progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate
cells in appropriate animals models.
Our goals are to understand and overcome the limitations of regeneration in the mammalian retina, so that endogenous retinal
cells are reprogrammed into an adult stem
cell and generate adequate
progenitor progeny to provide sufficient
cell numbers and types for
neuronal regeneration.
Towards our goals we study retinal
cells throughout their life, from embryonic stem
cells to retinal
progenitors to differentiating and mature neurons and glia — with one eye on
neuronal regeneration (meaning de-novo neurogenesis) in the mammalian retina — and with another eye on retinal disease pathomechanisms.
We hypothesize that upon retinal
neuronal damage MG or RPE
cells undergo defined and controlled changes in cellular and molecular phenotype towards a
cell with
progenitor properties — this process that we are studying we call regenerative reprogramming.
In detail, currently we investigate the underlying mechanisms that may lead to
cell cycle re-entry, so that Müller glia divide to self - renew and generate
progenitor and
neuronal progeny (see Figure).
This visualization shows tightly - packed DNA in a mouse
cell's nucleus at different stages of development, seen here in a semi-triangular form as a mature nerve
cell; in a roundish shape as a multipotent stem
cell; in a more oval form as a
neuronal progenitor; and as a more fragmented structure that shows how removing a specialized binding protein (HP1β knockout) affects the structure of the DNA - packing material, called heterochromatin, in a mature neuron.
These renderings show a tightly packed form of DNA called heterochromatin as it exists in a mouse
cell's nucleus at different stages of
cell development: a multipotent stem
cell (left), a
neuronal progenitor (middle), and a mature nerve
cell (right).
In the latest issue of
Neuronal Signaling, Tata and Ruhrberg discuss cellular and molecular interactions between neural
progenitor cells (NPCs) and blood vessels.