Not exact matches
«Since cholesterol is required by
neurons to form synapses (connections) with other cells, this
decrease in cholesterol could affect how nerves function for appetite regulation, behavior,
memory and even pain and motor activity,» says Dr. Kahn, who is also Mary K. Iacocca Professor of Medicine at Harvard Medical School.
In a study involving dietary ketosis via a low carbohydrate diet (less than 10 percent of total calories), compared to subjects on a 50 percent carbohydrate diet, the low - carbohydrate subjects demonstrated better performance on
memory tests, with higher scores being correlated to higher serum KB levels.14 A study using cultured mouse hippocampal cells showed that addition of the KB β - hydroxybutyrate (β - OHB) to cells exposed to Aβ resulted in no
decrease in the numbers of dendrites or total
neurons — two of the noted pathological changes in AD.
These include insoluble extracellular plaques made of beta - amyloid peptide (Aβ); intracellular neurofibrillary tangles (NFTs) resulting from the hyperphosphorylation of tau (a microtubule - associated protein); loss of hippocampal
neurons; a
decrease in production of brain acetylcholine; and a marked decline in glucose usage in regions of the brain associated with
memory and learning.5,11,20 - 22 All of these changes can be logically explained as the sequelae resulting from long - term dysregulation of insulin signaling and glucose metabolism.