Chen Gu and colleagues at The Ohio State University discovered that they could induce the formation of axonal varicosities in hippocampal
neurons grown in the lab by «puffing» them with bursts of liquid from a small pipette.
Promisingly, another drug called imipramine, which belongs to the second main class of antidepressants, had similar effects on miRNA - 1202 to citalopram, when applied to
neurons grown in the lab.
Not exact matches
At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor
neuron - like cells
grown in the
lab and thus are more likely to be the chief causes of brain - cell death
in these diseases.
In 2015, her lab published a paper in Cell (DOI: 10.1016 / j.cell.2015.04.012) that found that both adult and pediatric glioma cells grew faster when adjacent to highly active neuron
In 2015, her
lab published a paper
in Cell (DOI: 10.1016 / j.cell.2015.04.012) that found that both adult and pediatric glioma cells grew faster when adjacent to highly active neuron
in Cell (DOI: 10.1016 / j.cell.2015.04.012) that found that both adult and pediatric glioma cells
grew faster when adjacent to highly active
neurons.
To further explore nuclear transport's role
in Huntington's disease, Grima took
lab -
grown mouse
neurons and used chemical switches to a) turn on both an additional healthy copy of the RanGAP1 gene and a mutant version of Huntingtin; b) just turn on the mutant Huntingtin; or c) just turn on a healthy version of Huntingtin.
Scientists working to develop new treatments for neurodegenerative diseases have been stymied by the inability to
grow human motor
neurons in the
lab.
In 2010, the lab made the exciting breakthrough that dopamine neurons could be grown from human iPS cells and transplanted effectively to mitigate disease, setting the stage for forthcoming clinical trials in human
In 2010, the
lab made the exciting breakthrough that dopamine
neurons could be
grown from human iPS cells and transplanted effectively to mitigate disease, setting the stage for forthcoming clinical trials
in human
in humans.
Understanding this process enables Canals»
lab to
grow a huge number of
neurons in dishes
in the
lab - useful both for basic research and also as a source of healthy cells for experimenting with cell transplantation.