«Our study is the first to demonstrates unambiguously the conversion of a specific subtype of glia, the so - called NG2 glia, into induced
neurons in living animals,» says senior study author Benedikt Berninger of Johannes Gutenberg University Mainz.
Optogenetics has been able to activate single
neurons in living animals in milliseconds and reverse the intervention just as rapidly.
Before long, she struck up an acquaintance with Stanford University neuroscientist Karl Deisseroth, now celebrated for his pathbreaking work in optogenetics — an approach that uses light to control the firing of
neurons in living animals.
The lab studies the pathways from sensory input to behavioral output by quantitative analysis of behavior under well - defined conditions, genetic manipulation of animals or individual neuronal cells, and calcium imaging from
neurons in living animals.
Not exact matches
Direct recordings from the
neurons of
live mice showed the same pattern:
Animals that had gone through a stressful procedure had more bursting cells
in the lateral habenula.
When we suppressed the ALS mutation
in the brains of
animals, onset of the disease was delayed, the
animals lived longer, spinal motor
neurons survived longer, and the neuromuscular junctions stayed healthy longer,» said Svendsen, the Kerry and Simone Vickar Family Foundation Distinguished Chair
in Regenerative Medicine.
Finally, the researchers tested this circuitry
in live animals, artificially turning on the motor
neurons in anesthetized mice and then looking to see how the auditory cortex responded.
Since olfactory sensory
neurons regenerate throughout
life, even
in humans, the investigators were able to measure
neuron regeneration
in specific
animal models.
They counted the numbers of APs and ALs
in different body tissues — intestine, muscle, pharynx (i.e., the
animal's foregut), and
neurons — at different time points during the adult
life of C. elegans, and used chemical blockers to learn more about the dynamics of the process.
Albeanu and colleagues, including Arkarup Banerjee and Fred Marbach, graduate students
in the Watson School for Biological Sciences at CSHL and co-first authors of the
Neuron paper, conducted experiments
in living animals that revealed a mechanism for adjusting olfactory signal gain.
Some theoretical models suggested that new
neurons destabilize memories already stored
in the hippocampus by degrading the information there, but the idea had never been explored
in live animals.
For example, it could be used to image
neurons in living mice by combining the Raman scattering technique with existing methods
in which tiny windows are implanted
in the brains and spinal cords of laboratory
animals.
In a
live animal, these
neurons would then relay that information to the brain (Nature Photonics, DOI: 10.1038 / nphoton.2012.10).
THE firing of every
neuron in an
animal's body has been recorded,
live, for the first time.
This produced the proper layers of
neurons in the same order they arise
in living animals.
Using a mouse model of fragile X syndrome, the researchers recorded the activity of networks of
neurons in a
living mouse brain while the
animal was both awake and asleep.
Scientists have traditionally studied the neural basis of behavior
in live animals by using techniques such as stimulating
neurons with electrodes.
«Our earlier work was the first to clearly show
in vivo (
in a
living animal) that mature astrocytes can be reprogrammed to become functional
neurons without the need of cell transplantation.
This method uses light to precisely control the activity of specific
neurons in living, even moving,
animals in real time.
The researchers focused on a process — known as «homeostatic scaling down» — that has been well - studied
in lab
neurons but not before
in living animals.
In the worm, we are developing tools to monitor neuromodulation at cellular resolution in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living anima
In the worm, we are developing tools to monitor neuromodulation at cellular resolution
in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living anima
in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified
neurons using real - time approaches for imaging neuropeptide signaling,
in order to understand the dynamics of this process in a living anima
in order to understand the dynamics of this process
in a living anima
in a
living animal.
Then UC San Francisco's Arturo Alvarez - Buylla, PhD, and other neuroscientists discovered
in birds and mice that stem cells
in certain parts of the brain do produce new
neurons throughout the
animal's
life.
Restricted expression of UNC - 7S from the Punc - 7S promoter allowed us to recognize AVB: B motor
neuron gap junctions
in live animals and has served as a useful tool for examining changes
in synaptic connectivity [29].
The results
in many lab
animals are available, longer
life (40 %), less cancer, heart disease etc, more
neurons, less hypertension and diabetes..