When the mice died at 31 weeks, their brains had 20 % fewer
neurons than normal mouse brains in regions that Huntington's strikes in people.
Not exact matches
The researchers found that mutant
mice lacking Del - 1 had more severe attacks of the EAE
than normal mice, with more damage to myelin, the fatty sheath that coats
neurons and helps in the transmission of signals along the cell.
Chen and colleagues report online today in Science that
mice without GRPR
neurons scratched significantly less
than normal mice did — about 80 % less in each case.
Both
mice and humans with a silenced FMR1 gene have malformed
neurons: Spines on their dendrites are longer, thinner, and more numerous
than normal, and they also transmit weaker electric signals.
The brains of the
mice were smaller
than normal and had fewer
neurons in areas that controlled the affected behaviors.
To see what was happening in the brains of these ankyrin - G mutant
mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal
neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal
neurons in ankyrin - G mutant
mice than in
normal mice.
«The successful retrieval of memories in AD
mice by increasing the number of spines for
normal memory processing only in the memory cells, rather
than in a broad population of cells, highlights the importance of highly - targeted manipulation of
neurons and their circuits for future therapies.
«The successful retrieval of memories in AD
mice by increasing the number of spines for
normal memory processing only in the memory cells, rather
than in a broad population of cells, highlights the importance of highly - targeted manipulation of
neurons and their circuits for future therapies,» said Tonegawa in a statement.