Sentences with phrase «neutralizing abs»

A purified inactivated virus vaccine derived from a Puerto Rican strain was shown to induce ZIKV - specific neutralizing Abs and protect from virus challenge in mice and NHP models (115), and DNA vaccines encoding the prM / E genes of ZIKV elicited strong binding and neutralizing Abs in rhesus monkeys (116, 117).

Only two samples were found positive for neutralizing Abs to TMAdV: (1) Ab titers for the clinically ill researcher were 1 ∶ 32, and (2) Ab titers for one of the family members of the clinically ill researcher were 1 ∶ 8.

The decreased levels of neutralizing Abs to TMAdV in the researcher (1 ∶ 32) and a family member (1 ∶ 8) relative to those in infected titi monkeys (up to > 1 ∶ 512) are consistent with a recent study showing much higher levels of neutralizing antibodies in chimpanzees than in humans with adenovirus infections, possibly due to more robust adenovirus - specific T - cell responses in humans than in monkeys [45].

The clinical presentation, time of illness concurrent with the onset of the outbreak, and presence of neutralizing Abs in convalescent serum all strongly point to primary infection of the researcher by TMAdV.

Affected titi monkeys who died during the outbreak exhibited a wide range of neutralizing Ab titers, from < 1 ∶ 8 to > 1 ∶ 512 (those without Ab likely died before mounting a response).

In addition, an mRNA vaccine encoding the prM and E genes of a French Polynesian strain induced strong CD4 + T cell and neutralizing Ab responses in nonpregnant mice and protected mice and NHPs from virus challenge (118).

Not exact matches

de Jong YP, Dorner M, Mommersteeg MC, Xiao JW, Balazs AB, Robbins JB, Winer BY, Gerges S, Vega K, Labitt RN, Donovan BM, Giang E, Krishnan A, Chiriboga L, Charlton MR, Burton DR, Baltimore D, Law M, Rice CM, Ploss A. Broadly neutralizing antibodies abrogate established hepatitis C virus infection.