Sentences with phrase «neutralizing human»

The conserved membrane - proximal external region (MPER) of HIV - 1 gp41 is a target of the broadly neutralizing human monoclonal antibodies, 2F5 and 4E10.

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV - 1.

Watkins and Dennis Burton, Ph.D., chairman and professor of the Department of Immunology & Microbiology at the Scripps Research Institute, led the collaborative international study, «Neutralizing Human Monoclonal Antibodies Prevents Zika Virus Infection in Macaques,» published recently in Science Translational Medicine.

«Since it's impossible to predict which of these agents will cause the next epidemic, it would be ideal to develop a single therapy that could treat or prevent infection caused by any known ebolavirus,» says study co-leader Zachary A. Bornholdt, Ph.D., director of antibody discovery at Mapp Biopharmaceutical, Inc. «Our discovery and characterization of broadly neutralizing human antibodies is an important step toward that goal,» adds study co-leader, Kartik Chandran, Ph.D., professor of microbiology & immunology at Albert Einstein College of Medicine.

Sharon used molecular biology methods to express and purify the virus peptide and NMR spectroscopy to analyze its structure as it is bound to neutralizing human antibodies.

Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus.

HIV is trapped by acidic but not by neutralized human cervicovaginal mucus.

These same challenges exist for human allergy suffers, but recently there has been a major breakthrough in the development of a new, safe and effective therapy using a monoclonal antibody that specifically binds and neutralizes human IgE that is responsible for activating inflammation - producing cells.

You'll often hear claims that if we head into a long - lasting period similar to that, it will help neutralize human - caused global warming.

Not exact matches

When humans experience this harmony «they call it aesthetic experience Aesthetic experience is experience in which many influences vivify instead of neutralize one another and at the same time do not impair or destroy the clarity of consciousness....

Otherwise apathy and even disgust will pervade the human mass, neutralizing or reversing every vigorous impulse at the heart of Life.

And when the computers do make an impact in one way or another, humans just figure out a way to neutralize them regardless.

«Similarly, a number of studies have found that telling people about the 97 % scientific consensus on human - caused global warming has a neutralizing rather than polarizing effect.»

In people infected with HIV who develop broadly neutralizing antibodies, this antibody region — called HCDR3 — has about 30 amino acids, about twice as long as what is usual for human antibodies.

«We have followed a less potent neutralizing lineage in this particular individual before, but now we have found a far more potent antibody and have been able to study its development over six years,» said first author Mattia Bonsignori, M.D., of the Duke Human Vaccine Institute.

Researchers from the University of Zurich and University Hospital Zurich now reveal which factors are responsible for the human body forming such broadly neutralizing HIV antibodies, thereby opening new avenues for the development of an HIV vaccine.

The findings were published online today in the journal Immunity in a paper entitled, «Human circulating PD - 1 + CXCR3 - CXCR5 + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.»

Two new studies reveal that administering a potent, broadly neutralizing antibody that binds to HIV evokes a strong immune response in humans, and can even accelerate the clearance of infected cells.

Crushing, soaking, rinsing, and baking the root neutralizes the chemical and renders cassava safe for human consumption.

-- Hyperimmune globulin, prepared by purifying and concentrating plasma of immunized animals or previously infected humans with high titers (concentrations) of neutralizing antibody against Ebola virus, which have been shown to be protective in monkeys but are not currently available and would not be expected before mid-2015.

We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections.

«This panel of neutralizing antibodies offers the possibility of developing human monoclonal antibody - based immunotherapy, especially for health care workers,» noted the authors.

In laboratory studies reported in the Proceedings of the National Academy of Sciences (PNAS), the researchers found that these «neutralizing» antibodies prevented a key part of the virus, known as MERS CoV, from attaching to protein receptors that allow the virus to infect human cells.

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

If serum is tested on humans, it should be checked in advance that it can neutralize the virus, says Stephan Günther, a virologist at the Bernhard Nocht Institute for Tropical Medicine, who is now in Nigeria.

«If you relate this to human health, humans are primed with an initial vaccination series and then have neutralizing antibodies checked from time to time,» Moore said.

Furthermore, there is very limited similarity to the human germ line V gene VH1 - 2 * 02 precursor of the VRC01 - like broadly neutralizing antibodies isolated from multiple patients.

To date, immunizations in human and animal models have yielded antibodies with only limited ability to neutralize HIV [21], [22], [23], [24], except llama heavy chain only antibodies (HCAbs) isolated as individual variable regions (VHH)[25].

Our results show that immunization can induce potent and broadly neutralizing antibodies in llamas with features similar to human antibodies and provide a framework to analyze the effectiveness of immunization protocols.

To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV - 1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas.

The purified human antibodies had «potent neutralizing activity against both hantaviruses,» according to the paper's first author, Jay W. Hooper, Ph.D, of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

The residues altered were selected based on the observation that the three VHH described herein, B9, A14 and B21, bind to the RSC3 probe that was used to isolate the VRC01 - class of human CD4 binding site broadly neutralizing antibodies (Fig. 2) and that previously the introduction of an aromatic residue into the VRC01 - like antibody NIH45 - 46 resulted in increased breadth and potency [38].

They go on to say that «since no single broadly neutralizing antibody combines the entire range of mechanistic features anticipated to support in vivo efficacy, our study adds further evidence that combinations of such antibodies need to be considered for human application.»

Moreover, it is possible that the human IgG will be capable of interacting with the human immune system to neutralize and clear virus in ways that despeciated antibodies can not.

In our study, 2 of 81, or 2.5 % of random adult blood donors exhibited borderline titers of neutralizing antibody to TMAdV, indicating either a low prevalence of TMAdV in the human population or cross-reactivity to a related virus (although no evidence of cross-reactivity was found with HAdV serotypes 1 through 35).

Researchers at Vanderbilt University Medical Center and the University of Texas Medical Branch in Galveston (UTMB) reported this week in the journal Cell that they have isolated human monoclonal antibodies from Ebola survivors that can neutralize multiple species of the virus.

The team collected plasma from the cows, purified the human IgG antibodies, and tested the material for its ability to neutralize the two different viruses.

The decreased levels of neutralizing Abs to TMAdV in the researcher (1 ∶ 32) and a family member (1 ∶ 8) relative to those in infected titi monkeys (up to > 1 ∶ 512) are consistent with a recent study showing much higher levels of neutralizing antibodies in chimpanzees than in humans with adenovirus infections, possibly due to more robust adenovirus - specific T - cell responses in humans than in monkeys [45].

Pooled rabbit sera containing antibodies to human adenovirus serotypes 1 through 35, representing species A — E, were unable to neutralize TMAdV (data not shown).

The data would help researchers understand how microbes capture and store carbon dioxide from the atmosphere, how they break down organic matter so that plants can access its nutrients, and how they neutralize soil toxins known to threaten human health.

Fagete S, Ravn U, Gueneau F, Magistrelli G, Kosco - Vilbois MH, Fischer N. Specificity tuning of antibody fragments to neutralize two human chemokines with a single agent.

Specifically, she has convincingly demonstrated that the emotional expression of fear memories can be neutralized in humans (e.g., Nature Neuroscience, 2009), and which conditions are essential for this to occur (e.g., Science, 2013).

Dr. Leo Stamatatos, an immunologist in Fred Hutch's Vaccine and Infectious Disease Division, has received funding from the National Institutes of Health to begin manufacturing an HIV vaccine candidate designed to stimulate the production of broadly neutralizing antibodies and to test the experimental vaccine in human clinical trials.

Lack of preexisting virus - neutralizing antibodies in the human population suggests that these novel adenoviral recombinants may provide improved vaccine carriers for use in humans.

These viruses do not circulate in the human population and fail to carry neutralizing B cell epitopes that cross-react with the common serotypes of human adenoviruses.

Human monoclonal antibodies induced during Ebola infection are able to neutralize related viral species, scientists show.

Humans are infected by common serotypes of human adenovirus such as AdHu5 and a significant percentage has neutralizing antibodies to this serotypes, which impair the efficacy of AdHu5 based vaccines.

The trials would be for proof of concept, to show whether researchers can, for the first time in humans, stimulate the right B cells to start the process of making broadly neutralizing antibodies, long considered the «holy grail» of HIV vaccine research because they defend against infection by a broad spectrum of HIV strains.

Dr. Caskey and her team describe the first in human, phase 1 clinical trial of a first in class fully human highly neutralizing anti-HIV monoclonal antibody.

They are the means by which the virus enters human cells and they are the main targets of the neutralizing antibodies.