Instead of dying, cancer cells continue to grow and form
new abnormal cells.
Not exact matches
In the
new study, the scientists expressed surprise that the early
abnormal growth of brain
cells they observed in the fish embryo specifically affected male hormones, potentially indicating why more boys than girls are diagnosed with certain neurodevelopmental disorders such as autism.
The researchers have now provided further evidence for this
new theory by showing that the
abnormal protein coded for this genetic disorder can be transmitted to normal animals by the injection of diseased
cells into their brain.
The mouse models of autism on a normal lab diet (with a medium glycemic index) are already known to generate fewer
new neurons, and some of their existing
cells and neuronal connections are
abnormal compared with those of normal mice.
The
new study revealed that pancreatic cancer
cells not only send signals that make macrophages produce
abnormal amounts of dectin - 1 surface receptors, but also that make tumor
cells themselves express high levels of galectin - 9.
«The findings provide
new insight into how
cells faithfully transmit this organizational information as embryos develop, and into what goes wrong when cellular development goes awry, thereby giving rise to
abnormal cell development and diseases such as cancer,» says senior study investigator Danny Reinberg, PhD, professor of biochemistry and molecular pharmacology at NYU Langone and a Howard Hughes Medical Institute investigator.
The advancement could one day lead to a
new generation of medical sensors that are able to identify
abnormal cells.
Now, results of a
new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast
cells, acting as a tumor suppressor that halts
abnormal cell growth.
The
new study demonstrates how a wide range of mutations can be corrected in human
cells by eliminating
abnormal splice sites in the genomic DNA.
The
new research found that on top of their known effects on cancer, Hsp90 inhibition also blocked production of
abnormal forms of the androgen receptor, stripping cancer
cells of their defences against hormone treatments.
The cancer therapy, described today in two papers in Science Translational Medicine and The
New England Journal of Medicine, is based on the idea that the human body is already primed to fight
abnormal, dangerous
cells.
A
new biomarker could help identify
abnormal breast
cells that will develop into tumours, according to research published in Clinical Cncer Research.
Using a
new mouse model, we propose to test whether the spread of tangles through the brain is a result of
abnormal tau overwhelming the
cell's ability to clear it and whether we can boost
cell defenses against tangles using clinically approved drugs that have not been used for this purpose previously.
Our ambition is to interlink complementary biological and computational expertise so as to drive the generation of
new knowledge on the characteristics of normal and
abnormal stem
cells.
Abnormal cells in the early embryo are not necessarily a sign that a baby will be born with a birth defect such as Down's syndrome, suggests
new research carried out in mice at the University of Cambridge.
These
abnormal cells — in the case of pulmonary hypertension, those that line the blood vessels leading to the lungs — release signals that stimulate the growth of small
new blood vessels to feed the renegade
cells, allowing further proliferation, and thickening of the vessel walls.
IHEC aims to provide researchers with a comprehensive epigenomic analysis of healthy and
abnormal cells, and the
new studies constitute major strides toward that goal.
These
abnormal cells release signals that stimulate the growth of small
new blood vessels.