Sentences with phrase «new allele»

Besides ensuring correct chromosome segregation during the first meiotic division, crossovers create new allele combinations in gametes, thereby increasing genomic diversity, increasing the chance of creating offsprings with better phenotypic fitness, and providing the basis for faster evolution.

So, if a gene lies within a gene - dense, low - recombination region, then this means that a much larger number of progeny from crosses must be examined to find those that derive from rare recombinational events that separate the desired new allele from undesirable forms of neighboring genes.

Initially the people who drank milk from cows had something unusual about them, but by chance the new allele improved the welfare of human beings on their way north.

When this happens, the allele that wins becomes «fixed» and the only way to yield a new allele is through mutation and positive selection.

Their further analysis also provide evidence on the ancestral status of the Indian group, which holds great potential for introducing new alleles into the cultivated gene pool.

Their work, which is published in Nature Ecology and Evolution, shows for the first time the existence in Leishmania of a relation between changes in chromosome copy number and the selection of new alleles important for parasite survival.

When Parham compared the HLA genes of people from different regions of the world with the Neanderthal and Denisovan HLAs, he found evidence that non-African humans picked up new alleles from the hominins they interbred with.

We carried out a non-complementation screen for new alleles of unc - 124 and identified four new mutations.

Thereby, the model makes no assumptions about how new alleles have been evolved, whether by drift or natural selection.

All of these mutations mapped to the right of unc - 3 (+21.3 cM) and were presumed to be new alleles of unc - 7.

To continually produce more extreme variation despite these purifying forces requires the dog genome to create new alleles at an extraordinary rate.

Today, researchers are still trying to answer many questions about dominance relationships, new alleles, gene series, modifying factors, etc..

Many new alleles have been found for all three genes.

Many new alleles have been found for both of these genes.

Research at VetGen and independently at the University of Saskatchewan has identified two new alleles in the E locus, Eg and Eh.

Not exact matches

«If a new mutation arose in a certain population and it was strongly favored, natural selection would drive the frequency of that allele up very quickly,» he says.

With sexual reproduction, you will hopefully get a new combination of gene alleles that is more fit for whatever is coming down the pike,» King said.

Each Pm3 allele in the four new lines displayed the same activity as in the parental line, which results in increased overall activity, since it came from two different gene variations.

The predominant modern su1 allele was found in all of the older Mexican cobs, but the younger New Mexican cobs had several different alleles, suggesting that this gene was still undergoing selection when maize reached North America.

GC - biased gene conversion correlates with recombination rate (86), and new GC alleles reach fixation more easily in species with larger population sizes, which tend to also have smaller body sizes (87).

«When breeders make crosses to develop new varieties, they are seeking new combinations of alleles that are better suited to the agricultural environment or market for the crop product,» Close explained.

It also contains some of the most variable human genes: hundreds of versions — or alleles — exist of each gene in the population, allowing our bodies to react to a huge number of disease - causing agents and adapt to new ones.

A region inside the csd gene in particular represents a hot - spot with a high evolutionary rate that, together with certain amino acid mutations, decisively contributes to the formation of new csd alleles in the flanking regions.

New csd alleles were created in a relatively quick period for evolution: ca.

A new study published in the current issue of Biological Psychiatry suggests that even when controlling for the risk for Alzheimer's disease, the APOE ε4 allele also conveys an increased risk for late - life depression.

A naturally occurring variant in a different gene, the so - called APOE2 allele, has been previously shown to protect against Alzheimer's disease, but Stefansson says the new variant, while rarer, confers much greater protection.

SNP calling, genotype calling, and sample allele frequency estimation from new - generation sequencing data Nielsen, R. T. Korneliussen, A. Albrechtsen, Y. Li et al. 2012.

CVC researchers Danila Valmori and Maha Ayyoub identify a new NY - ESO - 1 epitope, 119 - 143 (core region 123 - 137), presented by HLA - DR52b (HLA - DRB3 * 0202), an MHC class II allele expressed by half of Caucasians, that is immunodominant in the context of vaccine - elicited immune responses.

The new passenger pigeons (birds carrying a fully edited set of alleles from each parent) will form the first true generation of de-extinct passenger pigeons.

Piroska Szabó of the Van Andel Research Institute in Grand Rapids, Michigan, was once excited to think she'd discovered a new gene that expressed only the maternal allele — until she realized that the RNA sequences she was looking at were from a gene that had been misannotated as a nuclear gene, explaining the maternal - only inheritance.

3) Allele replacement for precisely hybridizing a living species into an extinct species is the new genome - editing technique developed by George Church.

When Simon's team deleted all H3.3 genes, they found that certain previously silenced transposable elements were reactivated and continued to multiply in the genome — the result is the appearance of new genetic alleles and chromosomal abnormalities, both are familiar early events in the formation of tumors.

Any combination of somatic insertions or deletions (indels) in the p.R259fs allele that restored the reading frame before the stop - gain at residue 274, and did not produce a new stop - gain, would produce an almost full - length BRCA2 protein.

Rarecoal is a new framework to calculate the joint allele frequency spectrum across multiple populations using rare alleles.

A failure to identify new unc - 124 alleles led us to sequence the unc - 7 coding region cloned from unc - 124 (hs10) mutants (strain HH34), and a TGC to TAC change (C238Y) in the predicted second TM domain of UNC - 7 was identified.

The RECIPIENT (i) shall register the alleles carried by mice with a new mutation engineered from the MATERIAL with Mouse Genome Informatics (MGI), and (ii) is requested to submit breeding pairs to a public repository for cryopreservation and distribution to third parties for non-commercial purposes on terms substantially the same as these Conditions of Use.

We determined if the loci are under selection prior to the introduction of new drugs and established a baseline of genetic variance, including potential resistant alleles, for future surveillance programmes.

It was demonstrated in individuals living in a malaria endemic region of Papua New Guinea that Duffy binding protein adherence to RBCs is significantly reduced for erythrocytes of P. vivax malaria patients who carry one Duffy - negative allele [15].

Second, with over 20 commercially available C57BL / 6 substrains, many with known behavioral differences, we describe a framework to utilize mouse substrains as a rich genetic source for discovering new genes and alleles that regulate behavior.

New research shows that combination therapy of vitamin B3 and a fusion gene variant called the Wallerian degeneration slow allele prevented...

Although the newest edition of the authoritative textbook, Vitamin D, claims that in humans calcidiol binds with equal affinity to the DBP whether it is derived from vitamin D2 or vitamin D3, 37 the citation for this statement is the author's own PhD thesis, in which he reported results obtained from testing the DBP of a mere two people.48 Since the gene for the DBP is one of the most polymorphic known (meaning it exists in many forms), existing in three common alleles and 124 known rarer alleles (alleles are specific forms of the same gene), each allele itself having many polymorphisms, 37 a sample size of two is rather unconvincing.

New (or lost) alleles can be brought into a line by the simple expedient of outcrossing.

Even though these data are preliminary, the results present an opportunity to utilize new genotyping information by screening potential sires and dams for the disease - associated alleles for these nine SNPs and combine this information with current orthopedic screening schemes in breeding strategies to help further reduce the prevalence of patellar luxation in this breed.