Sentences with phrase «new cell signalling pathways»

Scientists at the Wyss Institute at Harvard University set out to solve the mystery of how blood flow keeps the vessels intact and, to their surprise, discovered a completely new cell signaling pathway that is a promising target for drugs to treat a variety of debilitating conditions.

Not exact matches

The new research, reported Nov. 25 in the Journal of Biological Chemistry, investigated the role of two proteins, GRB10 and p70S6K, in the control of the signaling pathway that activates M2 cells.

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die.

As a postdoctoral researcher at Harvard Medical School, he investigated the use of small - molecule drugs to manipulate signaling pathways to enable otherwise senescent progenitor cells of the cochlea to divide and form new sensory cells.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

In the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

We do not want to say that blood pressure medicine can cure toxoplasmosis, but we have discovered a new signalling pathway in immune cells that is linked to their motility and that the parasite utilizes in a very smart way.

A new study describes an improved protocol for the efficient differentiation of endothelial cells from pluripotent stem cell sources and highlights the importance of the MAPK and PI3K signaling pathways

Given the importance of G - protein signaling in cells, studies of downstream signaling pathways with the new Gα - blocking peptides are likely to reveal many new targets for future drugs, Sondek said.

Dr. Aldred's lab will evaluate a new therapeutic approach known as nonsense readthrough, testing two drugs that may be able to correct genetic defects in an important cell - signaling pathway.

The Herlyn Laboratory seeks to further define the various signaling pathways that work in cancer cells in order to discover new opportunities to inhibit cancer growth through targeted therapeutics.

Researchers discover a new regulatory pathway that channels signals emanating from a plant's extremities to the stem cell niche...

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

We note that our new results show that miR - 142 upregulates the expression of miR - 150 when miR - 142 is highly expressed and / or the Wnt signaling pathway is strongly stimulated in mammary epithelial cells.

(PhysOrg.com)-- Scientists at the University of Bonn have found a new signalling pathway which stimulates the production and function of so - called brown fat cells.

Published in the journal Cell Reports, this new research shows that this cell converting mechanism relies heavily on a major signaling pathway in the body involving a specific messenger called cCell Reports, this new research shows that this cell converting mechanism relies heavily on a major signaling pathway in the body involving a specific messenger called ccell converting mechanism relies heavily on a major signaling pathway in the body involving a specific messenger called cGMP.