According to a
new study, one reason may be that the
genes that set the body clock are intimately connected to our immune cells: Messing with the
circadian rhythm leads to messed - up immune cells.
Jeffrey Hall and Michael Rosbash of Brandeis University in Waltham, Massachusetts, and Michael Young of The Rockefeller University in
New York City share the prize equally for their work on how several
genes work together to control the basic
circadian clock, encoding proteins that build up during the night and are broken down during the day.
Some sleep disorders may be tied to specific genetic variants in the
genes underlying the
circadian rhythms, which may lead to
new ways of treating those disorders.
In indigenous Australians and Papua
New Guineans, mingling with the Denisovans (the «other Neanderthal,» an ancestral human living primarily in Asia) introduced
genes related to «spermatogenesis, fertilization, cold acclimation,
circadian rhythm, development of brain, neural tube, face, and olfactory pit, immunity,» as well as «female pregnancy, development of face, lung, heart, skin, nervous system, and male gonad, visual and smell perception, response to heat, pain, hypoxia, and UV, lipid transport, metabolism, blood coagulation, wound healing, aging.»
According to the article,
new research continues to «add to the growing recognition that our metabolisms are primed by the
circadian machinery written in our
genes, and that discord between the two can wreak havoc on our systems.»