Sentences with phrase «new drug screening»

With Intelligent Fingerprinting's new Drug Screening System, however, tests can be carried out within the mortuary from non-invasive fingertip sweat samples that are collected immediately as required outside a full post mortem examination.

Investigating the effectiveness of the ketogenic diet led researchers at the Cumming School of Medicine to develop a new drug screening method to discover drugs to treat epilepsy.

That led them to develop a new drug screening method that measures energy production in the background of a diseased brain.

Now, a group of researchers from Weill Cornell Medical College in New York City has devised a new drug screen that capitalizes on the tendency of toxic compounds to alter the properties of the lipid bilayer that encases cells.

Not exact matches

One program outlined in the White House spending plan clearly is new: an FDA Virtual Oncology Center of Excellence that will «leverage the combined skills of regulatory scientists and reviewers» to speed the development of cancer drugs, screening, and diagnostics.

Researchers are now trying to screen low molecular weight compounds for developing new anti-viral drugs.

«Our computer aided drug screening process has now identified two new classes of anti-cancer agents, specifically targeting two distinct and novel mechanisms underpinning cancer,» said Dr Andrea Brancale from Cardiff University's School of Pharmacy, who led on the compound's design.

With the engineered cells, researchers can screen new and existing drugs to see how they regulate alpha - synuclein level in patients.

One of the goals of the Center for Chromosome Biology is to establish screening techniques using small interfering RNAs (siRNAs) to find new targets for anticancer drugs, as well as gain a better understanding of fundamental cancer mechanisms.

«This gives us novel and exciting new therapeutic options to pursue based on results from drug screenings of primary tumor samples from patients.»

I think we will also be able to use stem cells in vitro to screen new drugs and see how they are likely to affect the people taking them, making prescriptions safer and more accurate.

The system can yield dose - response curves for candidate drugs, screen the phenotypes of large numbers of gene mutations, or execute complex custom protocols for completely new experiments.

Chemogenomics is a new concept where drug design and screening is conducted at the genome level for selective drug discovery effort against one target among a large family of related proteins / receptors.

Project 523 planned a three - pronged attack on drug - resistant malaria: research and develop new drugs the Western way, screen traditional medicine and folk remedies to search for a Chinese therapy, and find ways to prevent malaria infection in the first place.

«By understanding the mechanisms for these noxious effects,» says Hugh Hemmings, a professor of anesthesiology at Weill Cornell Medical College in New York City, «it gives you a way to screen for new drugs that don't have these effects, but do produce anesthesia.&raqNew York City, «it gives you a way to screen for new drugs that don't have these effects, but do produce anesthesia.&raqnew drugs that don't have these effects, but do produce anesthesia.»

In the new study, the researchers compared this standard of care to a screening approach where pregnant women are tested approximately monthly for malaria using rapid diagnostic tests and treated with a different drug, dihydroartemisinin - piperaquine (DP) only if they test positive for the parasite.

A therapeutic screening center, headed by Lee Rubin at the Harvard Department of Stem Cell and Regenerative Biology, is dedicated to using induced pluripotent stem cells to find new drugs for genetic diseases.

Knowing of America's desperate search for new antimalarial drugs (by then, the U.S. government and Winthrop scientists had screened roughly 14,000 candidate compounds), French military doctors shipped samples back to the States for further testing.

The advance, described in next month's issue of Nature Biotechnology, could lead to more accurate screening of organ donors and identification of genetic targets for new drugs.

The scientists say that having a model of blood - induced brain inflammation is a valuable tool, as it can be used to screen new drugs.

Target - based screening has enabled scientists to discover many useful new drugs, but some wonder whether this basic discovery strategy has already taken all the «low hanging fruit.»

With PhD student Carmen Lorenz at the MDC and the Berlin Institute of Health (BIH), he teamed up with other MDC researchers and scientists from France to come up with a new cell - based system to carry out drug screens.

Indeed, their combined phenotypic screening and target - identification approach enabled them to quickly discover, characterize and carry out preclinical tests of a potential new drug for obesity - linked diabetes: a complex metabolic disorder that affects 347 million people worldwide.

A new meta - analysis published online in PLOS ONE by infectious disease and epidemiology specialists from the Perelman School of Medicine at the University of Pennsylvania highlights significant gaps in hepatitis C care that will prove useful as the U.S. health care system continues to see an influx of patients with the disease because of improved screening efforts and new, promising drugs.

When the U.S. Food and Drug Administration screens new opioid drugs it should better anticipate how people might abuse them in the real world, the National Academies of Sciences, Engineering and Medicine warns in a major report issued Thursday on the country's opioid crisis, which kills 91 people a day — often via overdoses on prescription drugs.

For the moment, the team believe the technology could be used to grow artificial heart tissue for screening new drugs to regulate heart activity.

«The fact that we can induce a short seizure, of approximately 1 to 3 minutes long, with the exact timing of an electrical pulse, and that these worms react well to antiepileptic drugs, makes this new assay a perfect model for high - speed drug screens in multi-welled plate readers,» said Ken Dawson - Scully, Ph.D., corresponding author and associate professor in the Department of Biological Sciences and associate director of the FAU Brain Institute.

Other strategies for elimination will also include reinforced passive screening, new diagnostic tools and improved drugs.

Seeking to exploit this weakness and develop a new class of antifungals, an international group of researchers screened a synthetic drug library for compounds that target the synthesis of fungal but not mammalian GlcCer.

By introducing disease related mutations to the cells, researchers could study the onset and progression of the disease and gain new insights into the disease as well as screen and discover new treatment drugs.

Starting in 1996, when Congress passed the new Food Quality Protection Action with the Federal Food, Drug, and Cosmetic Act Amendments, it told EPA to develop a screening program using tests and other scientifically relevant information to determine whether substances have hormonal activity.

The screening procedure — used in the U.S. to model and study virus replication — allows for continuing evaluation of new antivirals or anti-Ebola drugs, since there is a likelihood of future Ebola outbreaks.

Not only could the new process ease the manufacture of existing protein therapeutics — and thus drop their price — but it could also speed the search for new so - called glycoprotein drugs, because researchers could easily attach different sugars to screen for the most effective combination.

This screening approach revealed several microRNA molecules that induce the process of cell differentiation, and those are key to developing new drugs.

«We wanted to see whether very - large - scale screening across a diverse collection of cancer cell lines and a large number of drugs could yield new combinations for patients with cancer,» says Adam Friedman, MD, PhD, of the CBRC and the MGH Cancer Center, who led the study.

Stubenhaus et al. also plan to use flatworms to screen for drugs that could potentially be developed into new treatments for porphyria.

Rao and her team hope that pinpointing the importance of this trafficking mechanism in autism spectrum disorders may lead to the development of new drugs for autism that alter endosomal pH. As the use of genomic data becomes increasingly commonplace in the future, the step-wise strategy devised by her team can be used to screen gene variants and identify at - risk patients, she says.

UNITY has completed a rigorous screening and preclinical testing process of candidate drugs, discovered in this study, and is launching a new clinical trial to assess its first drug, for patients with osteoarthritis of the knee this year.

«Our new high throughput drug screening has revealed the ATRA drug target, unexpectedly showing that ATRA directly binds, inhibits and ultimately degrades active Pin1 selectively in cancer cells.

«We're a long way from getting a new drug, but in the short term we may look at screening a variety of compounds to see if they have the potential to block HSP101.»

-- Drug design: we develop new virtual screening and chemoinformatics methods.

Caribou Biosciences, a developer of technology - based solutions for cellular engineering, today announced that it entered into a collaboration agreement with Novartis under which the two companies will utilize Caribou's proprietary CRISPR - Cas9 platform to research new CRISPR - based drug target screening and validation technologies.

A multidisciplinary team of scientists share recent advancements in innovative in - vitro cancer biology methods for screening drug - like molecules in cancer tissue relevant models in a new report published online ahead - of - print...

Illustrative of this approach, Caribou recently announced a collaboration agreement with Novartis Institutes for Biomedical Research under which the two companies will utilize Caribou's proprietary CRISPR - Cas9 platform to research new CRISPR - based drug target screening and validation technologies.

An alternative approach to detect new antitumor compounds is the screening of drugs approved for other indications for their efficacy against cancer cells.

The application of Dr. Snyder's techniques has enhanced the development of new agents in the pharmaceutical industry by enabling rapid screening of large numbers of candidate drugs.

Unraveling these mechanisms leads to new concepts and strategies for clinical intervention, including disease modeling, drug screening, and cell therapy.

«The advent of induced pluripotent stem cell technology has created exciting new approaches to model neurodevelopmental and neurodegenerative diseases for the study of pathogenesis and for drug screening,» said Prof. David Pleasure a co-author of the study.

«These findings not only offer a glimpse into how these powerful new models can shed light on disease mechanisms» said Dr. Miller, «They may also prove invaluable for screening potential drugs that could be developed into better treatments for Alzheimer's disease, FTD, and related conditions.»

The partnership uses Scripps Florida's high - throughput screening facilities to search for new drug targets.