Sentences with phrase «new drugs designed»
Serving as a Research Associate for Endometrin Pharmaceuticals, conducting research into new drugs designed to treat type 2 diabetes; creating trial protocols, working closely with ethics committees, verifying data, and writing detailed reports of findings.
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We're now testing new drugs designed to target and kill the cancer stem cells.
«Fitzpatrick and colleagues have paved the way for development of new drugs designed to prevent tangle formation by deciphering the molecular structure of the «tau» protein filaments that make up the tangles at atomic resolution.
The study could help identify people who would most benefit from new drugs designed to save brain cells, but more research is necessary to determine if the genetic mutations are implicated in disease.
A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).
Addyi, the new drug designed to spark sexual desire in women, has been available in the US since October 17.
«This work will fuel many functional and translational studies and allow for new drug design venues.»
This will provide a sound rationale for new drug design.»
Swedish researchers are developing a new drug designed to curb alcoholism.
Not exact matches
In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth of Otezla sales had dramatically slowed during Celgene's third fiscal quarter of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDA.
What Boger wants is to create a better way to develop drugs: through a process called structure - based design in which scientists build up a new drug, atom by atom, after determining the type of molecule that might interrupt the disease process.
«It essentially gives us a periodic table,» Ron DePinho, President of MD Anderson Cancer Center says, which has provided us with both diagnostic and therapeutic value as well as helped us design clinical trials to accelerate the development of new cancer drugs,».
Investigators have repeatedly touted the drug as a potential lynchpin in immuno - oncology, focusing on an enzyme that suppresses the immune cells Opdivo and a whole new class of PD - 1 / L1 checkpoints are designed to unleash in an attack on cancer cells.
I and others of like mind criticized the drug culture and related antics as a self - indulgent distraction from the goals of racial justice and peace, and worried that the new enthusiasm for «ecological consciousness» was in fact a conservative ploy designed to turn the movement away from the cause of the poor.
The psychoactive substances bill sought to crack down on legal highs — especially the new generation of drugs that are designed to mimic the effects of traditional illicit substances such as cannabis and ecstasy — which the Home Office says caused 129 deaths in 2015.
The $ 1.6 billion investment is designed to produce advanced cancer drugs and create hundreds of new jobs.
Mr Straw today committed the government to a new strategy designed to get prisoners off drugs, as well as helping offenders into work.
Meanwhile, Cuomo ended his three - day State of the State tour Wednesday with a speech in Albany that featured a renewed call for ethics reform and a proposal designed to cap the sky - high prices of prescription drugs in New York.
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.
«This discovery opens the way for the rational design of a new generation of antipsychotic drugs, hopefully with more desirable effects and fewer side effects.»
Dr Baker explained: «Our work has implications not only for understanding the basic science of protein folding and stability, but also for guiding the design and engineering of new proteins and drug molecules.»
Chemotherapy drugs designed to kill tumors may actually encourage ovarian cancer by stimulating the growth of cells that give rise to the malignancy, a new study finds.
Dr Webb said: «The results of our latest study open up the possibility of designing new drugs that use the same means to attack E. coli, but in a more effective way.»
The research team currently is working to identify new biomarkers that will allow them to develop a better understanding of how drug resistance develops, and how to best design effective combinations of medications that may improve patient responses.
As might be expected, this marriage of biology and technology is also designed to find new ways of diagnosing the disease, monitoring its progression and delivering drugs to fight it.
«Having the structure of the full - length Zika NS1 provides new information that can help guide the design of a potential vaccine or antiviral drugs,» said senior author Janet Smith, director of the Center for Structural Biology at the U-M Life Sciences Institute, where her lab is located, and professor of biological chemistry at the U-M Medical School.
Researchers at the Pharmacy Department of the CEU Cardenal Herrera University have published the design of a new bioadhesive ocular insert which is placed inside the eyelid and releases a larger amount of medicine through the cornea in a controlled way in the international journal Drug Delivery and Translational Research.
«Understanding how drug resistance develops can help in the design of new agents or strategies to overcome resistance,» says principal investigator Sameek Roychowdhury, MD, PhD, assistant professor of medicine and of pharmacology in the Division of Medical Oncology at the OSUCCC — James.
Therefore we believe that anti-VEGF treatment is a logical target for new drug treatments that could help enhance the effect of better lens design and placement, to prevent secondary cataract.»
His group has designed novel approaches to drug delivery systems, as well as new ways to engineer tissue.
«Our computer aided drug screening process has now identified two new classes of anti-cancer agents, specifically targeting two distinct and novel mechanisms underpinning cancer,» said Dr Andrea Brancale from Cardiff University's School of Pharmacy, who led on the compound's design.
Understanding how the virus operates offers a pathway to designing antiviral drugs as well as new vaccines to control bluetongue and related viral infections in animals and humans.
Researchers at the San Diego Supercomputer Center at the University of California, San Diego, have developed software that greatly expands the types of multi-scale QM / MM (mixed quantum and molecular mechanical) simulations of complex chemical systems that scientists can use to design new drugs, better chemicals, or improved enzymes for biofuels production.
Across many drug candidates, the team saw a several-fold increase in protein production using the new designs.
«A new field was starting in Greece — drug design — and there were not a lot of scientists who had been abroad and had been doing the specialized job that I was doing,» she says.
Phase 1 trials are typically only designed to determine if a new drug is safe, and can't answer whether a new drug works.
The team's results uncover a previously unknown, complex genomic landscape of this cancer, which can be used to design new personalized drug regimens for SS patients based on their unique genetic makeup.
The vexing problem is not going away, but the U.S. Food and Drug Administration today rolled out new plans designed to help stymie the shortages.
«It's possible that this is part of a new wave of drug treatments that are actually designed to address the immune defect,» says Phan.
«In addition to the potential of these genes and gene products to help us design new drugs, they could also serve as biomarkers for accurate diagnosis,» she says.
Today Brain publishes a new study indicating that antiepileptic drugs designed to reduce seizures, may also induce psychotic disorders in some patients.
Given the emergence of artemisinin resistance, these findings could potentially lead to the design of new treatments against drug - resistant parasites.
He's also likely to spur the FDA to follow the course laid out by agency cancer czar Richard Pazdur in speeding new approvals, possibly setting up a special unit aimed at orphan drugs to hasten OKs with smaller, better designed clinical trials.
Chemogenomics is a new concept where drug design and screening is conducted at the genome level for selective drug discovery effort against one target among a large family of related proteins / receptors.
• Penalties of up to $ 10 million may be imposed for violations of the new REMS (risk evaluation and mitigation strategy) provisions, designed to manage a known or potential serious risk associated with a drug or biological product.
Downing and the team evaluated the strength of clinical trial evidence supporting FDA approval decisions for new drugs by characterizing key features of efficacy trials, such as trial size, design duration, and end points.
Adams underscores that the ability to understand the configuration of atoms in molecular space can be used to generate new insights into drug design and development.
The researchers are using «big data» concepts and techniques to discover and design new nanomaterials — a priority area under the White House's Materials Genome Initiative — using a methodology that will revolutionize materials design, impacting a broad range of products that affect our daily lives, from drugs and agricultural chemicals such as pesticides or herbicides to fuel additives, paints and varnishes, and even personal care products such as shampoo.
Although SU101 is designed to sabotage messages from a particular messenger chemical, the approach could open the door to a range of new cancer drugs.
The discovery involved ORNL's Spallation Neutron Source, which provides the most intense pulsed neutron beams in the world for scientific research and industrial development, and ORNL's Titan supercomputer, the nation's most powerful for open science — a one - two punch for illuminating the physical properties of potential drugs that inform new design principles for safer, improved delivery platforms.