UT Southwestern Medical Center researchers successfully used
a new gene editing method to correct a mutation that leads to Duchenne muscular dystrophy (DMD) in a mouse model of the condition.
«
New gene editing method shows promising results for correcting Muscular Dystrophy.»
There has been much excitement among scientists about the power of
these new gene editing methods, and particularly about the CRISPR / Cas9 system, which is relatively simple to use and generally very efficient.
Not exact matches
Anderson and others are already exploring
new gene - delivery
methods, including nanoparticles, to better deliver
gene -
editing therapies to target tissues.
As CRISPR - Cas9 starts to move into clinical trials, a
new study published in Nature
Methods has found that the
gene -
editing technology can introduce hundreds of unintended mutations into the genome.
Their research team currently is testing the potential effect of the unique differences of the giraffe's FGFRL1
gene by introducing these changes into mice using the
new CRISPR
gene -
editing methods.
But to rid infected cells of HIV, Temple University researchers Kamel Khalili and Wenhui Hu customized a
new gene -
editing method called CRISPR to snip out the entire HIV genome without harming any human
genes.
Cellectis used an older
method called TALEN to target TCRαβ, but the revolutionary
new CRISPR
method has made it much easier and cheaper to create
gene -
editing tools.
Using next - generation sequencing, the U.K. team showed that the iPS cells» genome was «clean» — the
gene -
editing methods had not added any
new mutations.
«
New methods such the CRISPR - Cas9 system for
gene editing now make it possible to carry out functional studies in other species, and this will in turn lead to decisive advances in our understanding of early embryonic development in mammals.»
CRISPR / Cas9
gene editing is a rapidly growing field, and
new techniques and
methods are evolving accordingly.
In an email to The Post, Harvard University professor George Church, who wasn't involved in the
new paper, called it «a solid study worthy of celebration» but pointed out that
gene editing using the CRISPR
method is also coming along rapidly.
Two
newer gene -
editing methods — zinc finger nucleases, used since the late 1990s, and TALENs, first described in 2011 — allowed more precise modifications, he says, «but there was a real art and skill required, and only a handful of labs could do those.»
As CRISPR - Cas9 starts to move into clinical trials, a
new study published in Nature
Methods has found that the
gene -
editing technology can introduce hundreds of unintended mutations into the... Read more
A version of this article appears in print on February 2, 2016, on Page A4 of the
New York edition with the headline: Britain Allows
New Method to
Edit Genes.